154822-32-9Relevant academic research and scientific papers
Application of organolithium and related reagents in synthesis. Part 221. Synthetic strategies based on ortho-aromatic metallation. A concise regiospecific conversion of benzoic acids into the 4-pyridyl-2h-phthalazin- 1-ones
Brzezinski,Epsztajn,Bakalarz,LAjszczak,Malinowski
, p. 457 - 473 (2007/10/03)
The synthesis of phthalazin-1-ones 6, 7, 8 via the reaction of 3- hydroxyisoindolin-1-ones 3, 4, 5 with hydrazine hydrate is described. Starting compounds 3, 4, 5 were regiospecifically prepared upon the lithiation (n-BuLi) of the benzanilides 1 and subsequently the reaction of the dilithiated anilides 2 with methyl pyridinecarboxylates.
Application of organolithium and related reagents in synthesis. Part 14. Synthetic strategies based on aromatic metallation. A concise regiospecific conversion of benzole acids into their ortho-pyridoyl derivatives
Epsztajn, Jan,Jozwiak, Andrzej,Krysiak, Jerzy A.
, p. 2907 - 2916 (2007/10/02)
The synthesis of the 3-hydroxy-3-pyridyl-isoindolin-1-ones (5) and (6) via metallation (n-BuLi) of the benzanilides (1), and then the reaction of the generated bis lithiated anilides (2) with N,N-dimethylamides or methyl esters of pyridinecarboxylic acids (benzoylation reagents), and subsequent acidic hydrolysis of (5) and (6) as a way (general synthetic strategy) of regiospecific transformation of benzoic acids into their ortho-benzoylated derivatives, is described.
