15495-24-6Relevant academic research and scientific papers
Rhodium-catalyzed addition of alkynes to activated ketones and aldehydes
Dhondi, Pawan K.,Chisholm, John D.
, p. 67 - 69 (2006)
(Chemical Equation Presented) The rhodium-catalyzed addition of alkynes to 1,2-diketones, 1,2-ketoesters, and aldehydes provides a method for the synthesis of tertiary alkynyl alcohols under mild conditions. The reaction tolerates many functional groups (
Ligand effects in the rhodium-catalyzed addition of alkynes to aldehydes and diketones. Modification of the β-diketonate ligand
Dhondi, Pawan K.,Carberry, Patrick,Chisholm, John D.
, p. 8743 - 8746 (2007)
A catalytic amount of dicarbonylacetonato rhodium(I) and a phosphine ligand bearing bulky electron-donating alkyl groups has been shown to generate an effective catalyst for the addition of alkynes to aldehydes and activated ketones under mild, neutral conditions. While previous studies have shown that modification of the phosphine has significant effects on the activity of the catalyst, the role of the β-diketonate ligand has not been probed. Six different β-diketonate rhodium complexes were synthesized and their ability to catalyze the alkyne addition reaction was evaluated. Changing the structure of the β-diketonate ligand can have a noticeable effect on the reaction rate. Acetylacetonate derivatives with strong electron withdrawing groups have a detrimental effect on the catalytic activity, while bulky and electron rich β-diketonate derivatives provide more efficient catalysts.
Synthesis of heterocyclic systems by transition-metal-catalyzed cyclization-migration reactions - A diversity-oriented strategy for the construction of spirocyclic 3(2H)-furanones and 3-pyrrolones
Binder, Joerg T.,Crone, Benedikt,Kirsch, Stefan F.,Liebert, Clemence,Menz, Helge
, p. 1636 - 1647 (2008/02/06)
Two platinum(II)-catalyzed heterocyclization-migration reactions that provide five-membered heterocycle products are described. With 5 mol-% of PtCl2 as a catalyst, 2-alkynyl-2-hydroxy carbonyl compounds 1 are converted into 3(2H)-furanones 2 a
Addition of alkynes to aldehydes and activated ketones catalyzed by rhodium-phosphine complexes
Dhondi, Pawan K.,Carberry, Patrick,Choi, Lydia B.,Chisholm, John D.
, p. 9590 - 9596 (2008/03/17)
(Chemical Equation Presented) A mixture of 2-(di-tert-butylphosphino) biphenyl and dicarbonylacetonato rhodium(I) provides an effective catalyst system for the addition of alkynes to aldehydes and activated ketones. In contrast to the more common zinc-cat
