493-71-0

Usage

Classification

Furanone
A group of organic compounds containing a furan ring.

Appearance

Pale yellow liquid
The visual aspect of the compound in its pure form.

Usage

Synthesis of pharmaceuticals and other organic compounds
The compound serves as a building block or intermediate in creating various medicines and organic substances.

Molecular structure

Furan ring with two methyl groups and a phenyl group attached
The specific arrangement of atoms in the compound, which influences its properties and potential applications.

Biological and pharmacological activities

Antimicrobial and antioxidant properties
The compound has been studied for its potential effects on living organisms, including fighting infections and combating oxidative stress.

Potential applications

Development of new materials and as a flavoring agent in the food industry
The compound may have uses in creating innovative materials or enhancing the taste and aroma of food products.

Research interest

Diverse potential uses and further research and development
The compound's versatility and unique properties make it a valuable subject for ongoing investigation and exploration.

Upstream product

• 25461-80-7 4-methyl-4-hydroxy-1-phenylpent-2-yn-1-one 
• 109-89-7 diethylamine 
• 72795-77-8 4,5-Dibromo-2-hydroxy-2-methyl-5-phenyl-3-pentenone 
• 87064-08-2 (Z)-4-Bromo-1-diethylamino-4-methyl-1-phenyl-pent-1-en-3-one 
• 126247-73-2 (E)-4-benzoylmethylene-5,5-dimethyl-1,3-dioxolan-2-one 
• 26503-04-8 5-(2-hydroxyprop-2-yl)-3-phenylisoxazole 
• 108-86-1 bromobenzene 
• 201230-82-2 carbon monoxide 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 591-50-4 iodobenzene 
• 63677-96-3 (E)-2-hydroxy-2-methyl-5-phenylpent-4-en-3-one 
• 88865-31-0 5-acetoxy-2-methyl-5-phenyl-3-pentyn-2-ol 
• 591-51-5 phenyllithium 
• 87064-07-1 4-bromo-4-methyl-1-phenyl-pent-1-yn-3-one 

Downstream Products

• 5198-65-2 2,2-dimethyl-5-phenyl-furan-3-one-(2,4-dinitro-phenylhydrazone) 
• 84443-08-3 3-hydroxy-2,2-dimethyl-5-phenyl-3-phenylethynyl-2,3-dihydrofuran 
• 84443-10-7 3-hydroxy-2,2-dimethyl-5-phenyl-3-(1-propynyl)-2,3-dihydrofuran 
• 84443-11-8 3-hydroxy-2,2-dimethyl-5-phenyl-3-(t-butylethynyl)-2,3-dihydrofuran 
• 84443-09-4 3-hydroxy-2,2-dimethyl-5-phenyl-3-(p-tolylethynyl)-2,3-dihydrofuran 
• 84443-12-9 2,2-dimethyl-5-phenyl-3-(p-toluoylmethylene)-2,3-dihydrofuran 
• 84443-14-1 2,2-dimethyl-5-phenyl-3-(2-oxo-3,3-dimethylbutylidene)-2,3-dihydrofuran 
• 84443-13-0 2,2-dimethyl-5-phenyl-3-acetonylidene-2,3-dihydrofuran 
• 63838-74-4 2,2-dimethyl-5-phenyl-3-benzoylmethylene-2,3-dihydrofuran 

Relevant academic research and scientific papers

Cyclization of α-hydroxy-β-diketones to furan-3(2H)-ones under mild basic conditions

In relation with studies directed to the total synthesis of psuerotin A, conversion of α-hydroxy-β-diketones to the correspponding furan-3(2H)-ones have been successfully performed by a new method using K2CO3 in methanol. Cyclization

3(2H)-Furanones from Mercuric Acetate Oxidation of Allenic Ketones. A Synthesis of Bullatenone

Treatment of allenic ketones 1 with mercuric acetate yields 3(2H)-furanones 2 (90+percent).The oxidation of 1c constitutes a new synthesis of bullatenone (2c).

Synthesis of a 3(2H)-Furanone Derivative from Propargylic Alcohol, CO, and Phenyl Halide Catalyzed by Transition Metal Complexes

2-Methyl-3-butyn-2-ol reacted with CO and phenyl halides in the presence of a catalytic amount of transition metal complexes to afford 2,2-dimethyl-5-phenyl-3(2H)-furanone (bullatenone) under the influence of CO2.

Facile synthesis of 3(2H)-furanones

Abstract: A practical method for the synthesis of 3(2H)-furanones including the bullatenone was described. Intramolecular cyclization of 4-hydroxyalkynones in the presence of KOH affords the biologically potent furanones in moderate-to-good yield at room temperature. Synthesis of 4-hydroxyalkynones from the reaction of acid chloride and terminal alkyne in the presence of copper iodide at room temperature was also reported.

Synthesis of 5-Aryl-3(2 H)-furanones Using Intramolecular Cyclization of Sulfonium Salts

Base-induced intramolecular cyclization of novel (4-aryl-2,4-dioxobutyl)methylphenylsulfonium salts prepared from the commercially available 1-arylethanone by a cost-effective process is described in this paper. The reaction was completed within 10 min to produce a family of 2-unsubstituted 5-aryl-3(2H)-furanones in excellent yield. This procedure is simple, and can be carried out under mild conditions and an ambient atmosphere.

Cationic gold(I)-catalyzed intramolecular cyclization of γ-hydroxyalkynones into 3(2H)-furanones

"Chemical Equation Presented" The combination of (p-CF 3C6H4)3PAuCl and AgOTf generates a powerful catalyst for the intramolecular cyclizations of readily available y-hydroxyalkynones un-der mild conditions. The

Synthesis of heterocyclic systems by transition-metal-catalyzed cyclization-migration reactions - A diversity-oriented strategy for the construction of spirocyclic 3(2H)-furanones and 3-pyrrolones

Two platinum(II)-catalyzed heterocyclization-migration reactions that provide five-membered heterocycle products are described. With 5 mol-% of PtCl2 as a catalyst, 2-alkynyl-2-hydroxy carbonyl compounds 1 are converted into 3(2H)-furanones 2 a

Pd(II)-catalyzed cascade Wacker-Heck reaction: Chemoselective coupling of two electron-deficient reactants

A novel palladium(II)-catalyzed oxy-carbopalladation process was developed allowing for the orchestrated union of hydroxyynones with ethyl acrylate, two electron-deficient reactants. With β-hydroxy ynones, this cascade Wacker-Heck process gave access to highly functionalized tri- or tetrasubstituted dihydropyranones featuring an unusual dienic system. For diastereomerically pure and for enantioenriched β-hydroxyynones, these reactions proceed without affecting the stereochemical integrity of the existing stereocenters. In addition, tetrasubstituted furanones can be prepared when α-hydroxyynones and ethyl acrylate are used as starting materials. The dihydropyranones and furanones obtained upon cyclization are novel compounds, but structurally related carbohydrate derivatives featuring a similar dienic system have been used as starting materials for the construction of polyannulated products, suggesting that these cascade Pd(II)-mediated oxidative heterocyclizations are of value for various synthetic applications.

Synthesis of acetylenic ketones by a Pd-catalyzed carbonylative three-component coupling reaction in [bmim]PF6

A carbonylative three-component coupling reaction of aryl iodides with terminal alkynes catalyzed by PdCl2(PPh3)2 was carried out using an ionic liquid, [bmim]PF6, as the reaction medium, which resulted in good yields of α,β-acetylenic ketones. The low-viscosity ionic liquid, [bmim]NTf2, was not suitable for this reaction, since the background Sonogashira coupling reaction, a competing reaction, also proceeded.

Palladium-catalyzed oxidative cyclizations: Synthesis of dihydropyranones and furanones

A boron-mediated syn- and anti-stereoselective aldol reaction giving rise to various β-hydroxyenones was coupled to a Pd(II)-mediated oxidative cyclization to give 2,3,6-trisubstituted syn- and antidihydropyranones in good yields. The Pd(I