15497-48-0Relevant academic research and scientific papers
Synthesis and evaluation of hepatoprotective activity of some new mannich bases bearing benztriazole moiety
Rajasekaran, Aiyalu,Periyasamy, Muthusamy
experimental part, p. 366 - 370 (2011/10/30)
A series of benztriazoles bearing Mannich bases (2 -10) were synthesized from benztriazole by aminomethylation with formaldehyde and various substituted secondary amines. Titled compounds were synthesized by Mannich reaction and they were characterized by IR and 'HNMR spectroscopy. All these Mannich bases were screened for hepatoprotective activity on carbon tetrachloride induced liver damage in rats. Only compounds 4 (250 mg/kg) protected significantly the animals from carbon tetrachloride induced hepatotoxicity. Compound 4 N-morpholinyl methyl benztriazole exhibited significant activity comparable to that of standard drug silymarin.
Water-Tolerant Unstabilized Carbanion Equivalents: Bismuth(III) Chloride-Aluminum Promoted Alkylations of Immonium Cations to Amines in Aqueous Media
Katritzky, Alan. R.,Shobana, Navayath,Harris, Philip A.
, p. 4247 - 4248 (2007/10/02)
In the presence of bismuth(III) chloride-metallic aluminum, alkyl as well as allyl halides react with N-(alkylamino)benzotriazoles at 20 deg C in THF-water to give the corresponding homoalkylated amines in high yields.
