155004-78-7

Upstream product

• 326-59-0 benzo[1,3]dioxol-5-yl-acetic acid methyl ester 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 139148-39-3 methyl 3-oxo-3-(3,4,5-trimethoxyphenyl)propanoate 
• 717903-52-1 6-(trimethylsilyl)benzo[d][1,3]dioxol-5-yl triflate 

Downstream Products

• 1203549-63-6 C₁₉H₁₇NO₆ 
• 116097-18-8 6,7-methylenedioxy-1-(3',4',5'-trimethoxyphenyl)-2-benzopyran-3-one 
• 42123-26-2 dimethyl 6,7-methylenedioxy-1-(3',4',5'-trimethoxyphenyl)naphthalene-2,3-dicarboxylate 
• 116097-17-7 3,4-methylenedioxy-6-(3',4',5'-trimethoxybenzoyl)phenylacetic acid 

Relevant academic research and scientific papers

Expedient synthesis of 3-hydroxyisoquinolines and 2-hydroxy-1,4- naphthoquinones via one-pot aryne acyl-alkylation/condensation

A convenient method is disclosed for the synthesis of both 3-hydroxyisoquinolines and 2-hydroxy-1,4-naphthoquinones from β-ketoesters using a one-pot aryne acyl-alkylation/condensation procedure. When performed in conjunction with a one-step method for the synthesis of the β-ketoester substrates, this method provides a new route to these polyaromatic structures in only two steps from commercially available carboxylic acid starting materials. The utility of this approach is demonstrated in the synthesis of the atropisomeric P,N-ligand, QUINAP. The Royal Society of Chemistry 2009.

Synthesis of Podophyllum Lignans via an Isolable o-Quinonoid Pyrone

The 2-benzopyran-3-one 10 is a stable, isolable and useful Diels-Alder diene; its methyl 4-benzoyloxycrotonate adduct 23 formed regioselectively and stereoselectively in acetonitrile is reduced with H2/Pd to give 31 with inversion of C-1 stereochemistry.T