155153-78-9

Basic information

• Product Name: (2R,4S)-N-ALPHA-CARBOBENZOXY-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
• Synonyms: (2R,4S)-N-ALPHA-CARBOBENZOXY-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;N-ALPHA-CARBOBENZOXY-4-HYDROXY-D-PROLINE;Z-D-HYP-OH;(2R,4S)-N-ALPHA-BENZYLOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;N-CBZ-TRANS-4-HYDROXY-D-PROLINE;(4S)-1-Cbz-4-hydroxy-D-proline
• CAS NO: 155153-78-9
• Molecular Formula: C₁₃H₁₅NO₅
• Molecular Weight: 265.26
• Mol File: 155153-78-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 486.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.416±0.06 g/cm3(Predicted)
• PKA: 3.78±0.40(Predicted)
• CAS DataBase Reference: (2R,4S)-N-ALPHA-CARBOBENZOXY-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4S)-N-ALPHA-CARBOBENZOXY-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID(155153-78-9)
• EPA Substance Registry System: (2R,4S)-N-ALPHA-CARBOBENZOXY-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID(155153-78-9)

Safety Data

• Hazardous Substances Data: 155153-78-9(Hazardous Substances Data)

Usage

General Description

(2R,4S)-N-ALPHA-CARBOBENZOXY-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID is a chemical compound that belongs to the class of carboxylic acids. It is composed of a pyrrolidine ring with a carboxylic acid group attached at position 2, and a benzoxy group attached at position N. The 2R,4S stereochemistry indicates the configuration of the chiral centers in the molecule. (2R,4S)-N-ALPHA-CARBOBENZOXY-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID can be used in organic synthesis and as a building block in the creation of pharmaceuticals and other biologically active molecules. Its specific properties and potential applications would depend on the context within which it is being used.

Upstream product

• 501-53-1 benzyl chloroformate 
• 3398-22-9 trans-4-hydroxyproline 
• 142347-81-7 (2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride 
• 51-35-4 4R-4-hydroxyproline 
• 130930-25-5 (R,R)-4-hydroxy-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid 
• 2584-71-6 cis-hydroxy-D-proline 
• 155075-23-3 (2R,4R)-1-benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 

Downstream Products

• 79433-95-7 (2R,4S)-1-benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 79775-07-8 4S-O⁴(t-butyl)-D-Pro acid 
• 268729-12-0 4S-O⁴(t-butyl)-N₁-(fluorenylmethyloxycarbonyl)-D-proline 
• 1269622-71-0 (2S,4R)-4-fluoro-2-(1,3,5-trimethyl-1H-pyrazol-4-ylmethyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 1269622-64-1 (2R,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-[phenoxythiocarbonyloxy-(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]-pyrrolidine-1-carboxylic acid benzyl ester 
• 1269622-61-8 (2S,4S)-4-hydroxy-2-(1,3,5-trimethyl-1H-pyrazol-4-ylmethyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 1269622-60-7 (2S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-(1,3,5-trimethyl-1H-pyrazol-4-ylmethyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 1269622-59-4 (2R,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-[hydroxy-(1,3,5-trimethyl-1H-pyrazol-4-yl)-methyl]-pyrrolidine-1-carboxylic acid benzyl ester 
• 1269622-58-3 (2R,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-formyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 1269622-57-2 (2R,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 1269622-56-1 (2R,4S)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 1269622-40-3 (2R,4S)-4-benzyloxy-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 
• 1190194-20-7 dibenzyl (2R,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate 
• 1253791-74-0 (2R,4S)-2-Aminomethyl-4-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

EP300/CREBBP INHIBITOR

The present invention provides a compound having excellent histone acetyltransferase inhibitory activity against EP300 and/or CREBBP, or a pharmacologically acceptable salt thereof. The compound is represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein ring Q1, ring Q2, R1, R2, R3 and R4 respectively have the same meanings as defined in the specification.

HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES

The present teachings relate to compounds of Formula (I): and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, R4, R5, ring A, and Z are as defined herein

Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative

In response to various exogenous stimuli, mast cells (MCs) release a wide variety of inflammatory mediators stored in their cytoplasmic granules and this release initiates subsequent allergic reactions. Lysophosphatidylserine (lysoPS) has been known as an exogenous inducer to potentiate histamine release from MCs, though even at submicromolar concentrations. In this study, through SAR studies on lysoPS against MC degranulation, we identified lysoPT, a threonine-containing lysophospholipid and its 2-deoxy derivative as novel strong agonists. LysoPT and its 2-deoxy derivative induced histamine release from MCs both in vitro and in vivo at a concentration less than one-tenth that of lysoPS. Notably, lysoPT did not activate a recently proposed lysoPS receptor on MCs, GPR34, demonstrating the presence of another undefined receptor reactive to both lysoPS and lysoPT that is involved in MC degranulation. Thus, the present strong agonists, lysoPT and its 2-deoxy derivative, will be useful tools to understand the mechanisms of lysoPS-induced activation of degranulation of MCs. 2009 American Chemical Society.