15516-73-1Relevant academic research and scientific papers
Thermal Z-E Isomerization of Azobenzenes. The Pressure, Solvent, and Substituent Effects
Asano, Tsutomu,Okada, Toshio
, p. 4387 - 4391 (1984)
The rates of thermal Z-E isomerization of 4-(dimethylamino)-4'-nitroazobenzene were measured in a variety of solvents, and the Kirkwood plot revealed that the rate constant increase is much larger in polar solvents than expected from the continuum theory.
Design of phase-transition molecular solar thermal energy storage compounds: compact molecules with high energy densities
Qiu, Qianfeng,Gerkman, Mihael A.,Shi, Yuran,Han, Grace G. D.
supporting information, p. 9458 - 9461 (2021/09/22)
A series of compact azobenzene derivatives were investigated as phase-transition molecular solar thermal energy storage compounds that exhibit maximum energy storage densities around 300 J g?1. The relative size and polarity of the functional g
A photochromic agonist for μ-opioid receptors
Schoenberger, Matthias,Trauner, Dirk
, p. 3264 - 3267 (2014/04/03)
Opioid receptors (ORs) are widely distributed in the brain, the spinal cord, and the digestive tract and play an important role in nociception. All known ORs are G-protein-coupled receptors (GPCRs) of family A. Another well-known member of this family, rhodopsin, is activated by light through the cis/trans isomerization of a covalently bound chromophore, retinal. We now show how an OR can be combined with a synthetic azobenzene photoswitch to gain light sensitivity. Our work extends the reach of photopharmacology and outlines a general strategy for converting Family A GPCRs, which account for the majority of drug targets, into photoreceptors. Lighting up the opioid receptor: Photofentanyl-2 is a photochromic version of the well-known analgesic fentanyl. It is a potent agonist in the dark (or when illuminated with blue light) and loses activity when irradiated with UV light. It can be used to optically control the μ-opioid receptor, converting a G-protein-coupled receptor (GPCR) into a photoreceptor.
