155192-16-8

Upstream product

• 155192-03-3 (1R, 2R, 4S, 5S, 6R, 4'S)-5-hydroxymethyl-4-methoxymethyloxy-1-methyl-6-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)bicyclo<2.2.2>octan-2-ol 
• 155192-04-4 (1S, 2S, 3R, 4R, 5R, 4'S)-5-benzyloxy-2-benzyloxymethyl-1-methoxymethyloxy-4-methyl-3-(2',2'-dimethyl-1',3'-dioxolan-4'yl)bicyclo<2.2.2>octane 
• 147728-68-5 methyl (1S, 2R, 3R, 4R, 4'S)-1-methoxymethyloxy-4-methyl-3-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-5-oxobicyclo[2.2.2]octane-2-carboxylate 
• 100-39-0 benzyl bromide 
• 81703-93-7 methyl (2E)-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate 

Relevant academic research and scientific papers

Total Synthesis of Upial, a Marine Sesquiterpene Possessing Bicyclononane Ring System

The total synthesis of marine sesquiterpene upial was achieved starting from D-mannitol via sequential Michael reaction of the lithium enolate of 5 with methyl (E,S)-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-pentenoate ((E)-6), fragmentation reaction of tricycli