15521-65-0

Basic information

• Product Name: Nickel bis(dimethyldithiocarbamate)
• Synonyms: Bis(dimethyldithiocarbamic acid)nickel(II) salt;Ai3-50831;Bis(dimethylcarbamodithioato-S,S')nickel;Einecs 239-560-8;N,N-Dimethyldithiocarbamate nickel salt;METHYL NICLATE;bis(dimethyldithiocarbamato) nickel complex;Nickel bis(dimethyldithiocarbamate)
• CAS NO: 15521-65-0
• Molecular Formula: C₆H₁₂N₂NiS₄
• Molecular Weight: 299.13
• EINECS: 239-560-8
• Product Categories: Organometallics
• Mol File: 15521-65-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: >290°C
• Boiling Point: 488.62°C (estimate)
• Flash Point: 32 °C
• Appearance: COA
• Density: 1,77 g/cm3
• Vapor Pressure: 10.2mmHg at 25°C
• CAS DataBase Reference: Nickel bis(dimethyldithiocarbamate)(CAS DataBase Reference)
• NIST Chemistry Reference: Nickel bis(dimethyldithiocarbamate)(15521-65-0)
• EPA Substance Registry System: Nickel bis(dimethyldithiocarbamate)(15521-65-0)

Safety Data

• Statements: 20/21/22
• Safety Statements: 22-36/37/39
• TSCA: No
• Hazardous Substances Data: 15521-65-0(Hazardous Substances Data)

Usage

Safety Profile

Confirmed human carcinogen.Mildly toxic by ingestion.

InChI:InChI=1/2C3H7NS2.Ni/c2*1-4(2)3(5)6;/h2*1-2H3,(H,5,6);/q;;+2/p-2

Upstream product

• 83202-02-2 Ni((CH₃)2NCS₂)3⁽¹⁺⁾*NO₃^(1-) = [Ni((CH₃)2NCS₂)3]NO₃ 
• 128-04-1 sodium dimethyldithiocarbamate 
• 63576-43-2 Ni((CH₃)2NCS₂)3⁽¹⁺⁾*BF₄^(1-) = [Ni((CH₃)2NCS₂)3]BF₄ 
• 7440-02-0 nickel 
• 137-26-8 Thiram 

Relevant articles and documents

Induction of Necroptosis in Cancer Stem Cells using a Nickel(II)-Dithiocarbamate Phenanthroline Complex

The cytotoxic properties of a series of nickel(II)-dithiocarbamate phenanthroline complexes is reported. The complexes 1–6 kill bulk cancer cells and cancer stem cells (CSCs) with micromolar potency. Two of the complexes, 2 and 6, kill twice as many breast cancer stem cell (CSC)-enriched HMLER-shEcad cells as compared to breast CSC-depleted HMLER cells. Complex 2 inhibits mammosphere formation to a similar extent as salinomycin (a CSC-specific toxin). Detailed mechanistic studies suggest that 2 induces CSC death by necroptosis, a programmed form of necrosis. Specifically, 2 triggers MLKL phosphorylation, oligomerization, and translocation to the cell membrane. Additionally, 2 induces necrosome-mediated propidium iodide (PI) uptake and mitochondrial membrane depolarisation, as well as morphological changes consistent with necroptotosis. Strikingly, 2 does not evoke necroptosis by intracellular reactive oxygen species (ROS) production or poly(ADP) ribose polymerase (PARP-1) activation.