1552270-25-3

Basic information

• Product Name: 4-bromo-2-[(4-fluorophenyl)carbamoyl]phenyl diethyl phosphate
• Synonyms: 4-bromo-2-[(4-fluorophenyl)carbamoyl]phenyl diethyl phosphate
• CAS NO: 1552270-25-3
• Molecular Weight: 446.21
• Mol File: 1552270-25-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-bromo-2-[(4-fluorophenyl)carbamoyl]phenyl diethyl phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-2-[(4-fluorophenyl)carbamoyl]phenyl diethyl phosphate(1552270-25-3)
• EPA Substance Registry System: 4-bromo-2-[(4-fluorophenyl)carbamoyl]phenyl diethyl phosphate(1552270-25-3)

Safety Data

• Hazardous Substances Data: 1552270-25-3(Hazardous Substances Data)

Upstream product

• 7103-85-7 5-Bromo-N-(4-fluoro-phenyl)-2-hydroxy-benzamide 
• 814-49-3 diethyl chlorophosphate 
• 89-55-4 5-bromosalicyclic acid 
• 371-40-4 4-fluoroaniline 

Relevant articles and documents

Salicylanilide diethyl phosphates: Synthesis, antimicrobial activity and cytotoxicity

A series of 27 salicylanilide diethyl phosphates was prepared as a part of our on-going search for new antimicrobial active drugs. All compounds exhibited in vitro activity against Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium strains, with minimum inhibitory concentration (MIC) values of 0.5-62.5 μmol/L. Selected salicylanilide diethyl phosphates also inhibit multidrug-resistant tuberculous strains at the concentration of 1 μmol/L. Salicylanilide diethyl phosphates also exhibited mostly the activity against Gram-positive bacteria (MICs ≥1.95 μmol/L), whereas their antifungal activity is significantly lower. The IC50 values for Hep G2 cells were within the range of 1.56-33.82 μmol/L, but there is no direct correlation with MICs for mycobacteria.