1552278-85-9Relevant academic research and scientific papers
Synthesis of allylated quinolines/isoquinolines via palladium-catalyzed cyclization-allylation of azides and allyl methyl carbonate
Luo, Jiang,Huo, Zhibao,Fu, Jun,Jin, Fangming,Yamamoto, Yoshinori
supporting information, p. 3227 - 3235 (2015/03/18)
A novel and efficient strategy for one-step synthesis of allylated quinolines and isoquinolines via palladium-catalyzed cyclization-allylation of azides and allyl methyl carbonate is developed for the first time. The results indicated that the regioselective synthesis of allyl- and diallyl-substituted quinolines/isoquinolines depends on different substituted groups at R1 and R4 positions, such as H or other groups. The reactions proceed smoothly in the presence of Pd(PPh3)4 and K3PO4 or NaOAc in DMF at 100°C to give the corresponding allyl- and diallyl-substituted quinolines and isoquinolines in good to high yields.
Efficient approach to allylated quinolines via palladium-catalyzed cyclization-allylation of 1-azido-2-(2-propynyl) benzenes with allyl methyl carbonate
Luo, Jiang,Huo, Zhibao,Fu, Jun,Jin, Fangming,Yamamoto, Yoshinori
supporting information, p. 1552 - 1556 (2014/03/21)
The palladium-catalyzed cyclization-allylation reaction of ortho-azido propynylbenzenes 1 and allyl methyl carbonate 2d gives the corresponding allylated quinolines in moderate to good yields. The reaction of 1-azido-2-(2-propynyl)benzene 1a proceeds smoo
