155251-72-2 Usage
Uses
Used in Pharmaceutical Industry:
(R)-tert-butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate is used as an impurity in the drug Teneligliptin, which is a DPP-4 inhibitor for the treatment of type 2 diabetes. Its presence is significant for quality control and safety assessments of the medication, ensuring that the therapeutic agent is effective and free from harmful side effects.
Additionally, understanding the properties and effects of (R)-tert-butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate can aid in the development of new drugs or the improvement of existing ones, potentially impacting the treatment of diabetes and related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 155251-72-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,5,2,5 and 1 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 155251-72:
(8*1)+(7*5)+(6*5)+(5*2)+(4*5)+(3*1)+(2*7)+(1*2)=122
122 % 10 = 2
So 155251-72-2 is a valid CAS Registry Number.
155251-72-2Relevant academic research and scientific papers
Synthesis of prolyl endopeptidase inhibitors and evaluation of their structure-activity relationships: In vitro inhibition of prolyl endopeptidase from canine brain
Arai,Nishioka,Niwa,Yamanaka,Tanaka,Yoshinaga,Kobayashi,Miura,Ikeda
, p. 1583 - 1588 (2007/10/02)
By chemical modification of a known prolyl endopeptidase (PEP) inhibitor (N-[N-(4-phenylbutanoyl)-L-prolyl]pyrrolidine; SUAM-1221), several arylalkanoyl derivatives (V-1-27) were synthesized and tested for in vitro inhibitory activity towards PEP from canine brain. Among them, 4-(2- thienyl)butanoyl derivatives (V-24-27) showed more potent PEP-inhibitory activity than SUAM-1221. The structure-activity relationships of these compounds are discussed.
