155366-03-3Relevant academic research and scientific papers
The Silicon-Hydrogen Exchange Reaction: A Catalytic σ-Bond Metathesis Approach to the Enantioselective Synthesis of Enol Silanes
Zhou, Hui,Bae, Han Yong,Leutzsch, Markus,Kennemur, Jennifer L.,Bécart, Diane,List, Benjamin
supporting information, p. 13695 - 13700 (2020/08/24)
The use of chiral enol silanes in fundamental transformations such as Mukaiyama aldol, Michael, and Mannich reactions as well as Saegusa-Ito dehydrogenations has enabled the chemical synthesis of enantiopure natural products and valuable pharmaceuticals. However, accessing these intermediates in high enantiopurity has generally required the use of either stoichiometric chiral precursors or stoichiometric chiral reagents. We now describe a catalytic approach in which strongly acidic and confined imidodiphosphorimidates (IDPi) catalyze highly enantioselective interconversions of ketones and enol silanes. These "silicon-hydrogen exchange reactions"enable access to enantiopure enol silanes via tautomerizing σ-bond metatheses, either in a deprotosilylative desymmetrization of ketones with allyl silanes as the silicon source or in a protodesilylative kinetic resolution of racemic enol silanes with a carboxylic acid as the silyl acceptor.
LIQUID CRYSTALLINE COMPOUND HAVING DIFLUOROMETHYLENEOXY GROUP, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT
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Paragraph 0158; 0160, (2018/04/03)
PROBLEM TO BE SOLVED: To provide a liquid crystalline compound having at least one sufficient property in physical properties such as high stability to heat or light, a high clear point (or high maximum temperature), a low minimum temperature of a liquid
Liquid crystal compound containing 5-cyclobutyl-1,3-dioxy cyclohexane structure, preparation method and applications thereof
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Paragraph 0135; 0136; 0137, (2016/10/08)
The present invention discloses a liquid crystal compound containing 5-cyclobutyl-1,3-dioxy cyclohexyl and a difluoromethyleneoxy linking group, a preparation method and applications thereof, wherein the compound is represented by a formula I. According t
Fluorinated compounds containing naphthalene structure
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Paragraph 0140, (2016/11/17)
PROBLEM TO BE SOLVED: To provide a compound concurrently having a large dielectric anisotropy (Δε), a high clear point (T) and a low viscosity (η), and to provide a liquid crystal composition and a liquid crystal display element including the above compou
Compound having 2-fluorophenyloxymethane structure
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Page/Page column 168; 169; 171, (2015/12/01)
There is provided a compound having a good miscibility with another liquid crystal compound and having a combination of a low viscosity (η), high storage stability, and high T?i even after being used to produce a liquid crystal composition. In
ORTHO ESTER DERIVATIVE, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT
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Paragraph 0397, (2014/02/15)
The invention is to provide a liquid crystal compound having a large dielectric anisotropy, a high voltage holding ratio and stability to heat, light and so forth, maintaining a nematic phase in a wide temperature range, having a suitable optical anisotropy and an excellent compatibility with other liquid crystal compounds, particularly, to provide a liquid crystal compound having a large dielectric anisotropy. The invention provides compound (1): In the formula, for example, R1 is alkyl and having 1 to 20 carbons; ring A1, ring A2, ring A3, ring A4, ring A5 and ring A6 are independently 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2, Z3, Z4, Z5, Z6 and Z7 are independently a single bond, - (CH2) 2-, -COO-, -OCO-, CF2O-, -OCF2- or -CH=CH-; X1 is fluorine, -CF3 or -OCF3; and Y1 and Y2 are independently hydrogen or fluorine.
COMPOUND HAVING 2-FLUOROPHENYLOXYMETHANE STRUCTURE
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Paragraph 0145; 0151, (2014/09/30)
The present invention relates to a compound having a 2-fluorophenyloxymethane structure and useful for organic electronic materials and medical and agricultural chemicals, particularly materials for liquid crystal display elements. A problem to be solved
Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A
Ding, Fa-Xiang,Shen, Hong C.,Wilsie, Larrisa C.,Krsmanovic, Mihajlo L.,Taggart, Andrew K.,Ren, Ning,Cai, Tian-Quan,Wang, Junying,Tong, Xinchun,Holt, Tom G.,Chen, Qing,Gerard Waters,Hammond, Milton L.,Tata, James R.,Colletti, Steven L.
scheme or table, p. 3372 - 3375 (2010/08/06)
A series of pyrazolyl propionyl cyclohexenamides were discovered as full agonists for the high affinity niacin receptor GPR109A. The structure-activity relationship (SAR) studies were aimed to improve activity on GPR109A, reduce Cytochrome P450 2C8 (CYP2C
Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment
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Page/Page column 60-61, (2009/04/24)
The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
Discovery of novel orally active ureido NPY Y5 receptor antagonists
Li, Guoqing,Stamford, Andrew W.,Huang, Ying,Cheng, Kuo-Chi,Cook, John,Farley, Constance,Gao, Jun,Ghibaudi, Lorraine,Greenlee, William J.,Guzzi, Mario,van Heek, Margaret,Hwa, Joyce J.,Kelly, Joe,Mullins, Deborra,Parker, Eric M.,Wainhaus, Sam,Zhang, Xiaoping
, p. 1146 - 1150 (2008/09/18)
We have derived a novel series of neuropeptide Y (NPY) Y5 receptor antagonists from the biphenylurea 3. Cyclohexylurea 21c, a member of the series, is a potent NPY Y5 receptor antagonist that exhibits excellent pharmacokinetic parameters in rats and dogs. On chronic oral administration to diet-induced obese rats, 21c displayed an anti-obesity profile, causing a modest reduction in food intake, a significant decrease in body weight gain, a decrease in adipose mass, and an increase in lean tissue mass.
