155366-02-2

Usage

Structure

Spiroketone with a dioxaspirodecene framework
The compound features a spiro carbon atom connecting a six-membered oxygen heterocycle to a seven-membered carbon ring.
3. 3,5-Difluorophenyl substituent
A phenyl group with two fluorine atoms attached at the 3rd and 5th positions, which is attached to the spiro carbon atom.

Potential applications

Pharmaceutical and materials science
The unique chemical properties of the compound make it a candidate for further research in the development of novel drugs or materials.

Further research and development

Possible discovery of new drugs or materials
Ongoing studies and development of 1,4-Dioxaspiro[4.5]dec-7-ene, 8-(3,5-difluorophenyl)- may lead to the identification of new substances with specific properties and applications.

Chemical properties

Influenced by the 3,5-difluorophenyl substituent
The presence of the difluorophenyl group on the spiro carbon atom imparts unique chemical properties to the compound, which can be exploited in various applications.

Stability

Unknown, but potentially influenced by the dioxaspirodecene structure and the 3,5-difluorophenyl substituent
The stability of the compound may be affected by the presence of the oxygen heterocycle and the fluorinated phenyl group, which could impact its reactivity and shelf life.

Solubility

Unknown, but may be influenced by the polar oxygen atoms and the fluorinated phenyl group
The solubility of the compound in various solvents is not provided, but it can be inferred that the presence of polar oxygen atoms and the electronegative fluorine atoms may affect its solubility profile.

Reactivity

Unknown, but may be influenced by the spiro carbon atom and the dioxaspirodecene structure
The reactivity of the compound is not specified, but the presence of the spiro carbon atom and the dioxaspirodecene framework may contribute to its reactivity with other chemical species.

Synthesis

Not provided in the material, but likely involves the formation of the dioxaspirodecene framework and subsequent introduction of the 3,5-difluorophenyl group
The synthesis of the compound is not described in the material, but it can be inferred that the process involves the formation of the spiro carbon atom and the dioxaspirodecene structure, followed by the introduction of the 3,5-difluorophenyl substituent.

Upstream product

• 4746-97-8 cyclohexanedione monoethylene ketal 
• 461-96-1 3,5-difluorobromobenzene 
• 680596-79-6 4,4,5,5-tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane 
• 1580472-97-4 potassium (1,4-dioxaspiro[4.5]dec-7-en-8-yl)trifluoroborate 
• 156545-07-2 3,5-difluorophenylboronic acid 
• 170011-47-9 1,4-dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate 
• 155366-01-1 4-(3,5-difluorophenyl)-4-hydroxycyclohexanone ethylene ketal 

Downstream Products

• 155366-03-3 4-(3,5-difluorophenyl)cyclohexanone ethylene ketal 
• 156265-95-1 4-(3,5-difluorophenyl)cyclohexan-1-one 

Relevant academic research and scientific papers

Electro-Olefination—A Catalyst Free Stereoconvergent Strategy for the Functionalization of Alkenes

Conventional methods carrying out C(sp2)?C(sp2) bond formations are typically mediated by transition-metal-based catalysts. Herein, we conceptualize a complementary avenue to access such bonds by exploiting the potential of electrochemistry in combination with organoboron chemistry. We demonstrate a transition metal catalyst-free electrocoupling between (hetero)aryls and alkenes through readily available alkenyl-tri(hetero)aryl borate salts (ATBs) in a stereoconvergent fashion. This unprecedented transformation was investigated theoretically and experimentally and led to a library of functionalized alkenes. The concept was then carried further and applied to the synthesis of the natural product pinosylvin and the derivatization of the steroidal dehydroepiandrosterone (DHEA) scaffold.

The Silicon-Hydrogen Exchange Reaction: A Catalytic σ-Bond Metathesis Approach to the Enantioselective Synthesis of Enol Silanes

The use of chiral enol silanes in fundamental transformations such as Mukaiyama aldol, Michael, and Mannich reactions as well as Saegusa-Ito dehydrogenations has enabled the chemical synthesis of enantiopure natural products and valuable pharmaceuticals. However, accessing these intermediates in high enantiopurity has generally required the use of either stoichiometric chiral precursors or stoichiometric chiral reagents. We now describe a catalytic approach in which strongly acidic and confined imidodiphosphorimidates (IDPi) catalyze highly enantioselective interconversions of ketones and enol silanes. These "silicon-hydrogen exchange reactions"enable access to enantiopure enol silanes via tautomerizing σ-bond metatheses, either in a deprotosilylative desymmetrization of ketones with allyl silanes as the silicon source or in a protodesilylative kinetic resolution of racemic enol silanes with a carboxylic acid as the silyl acceptor.

Method for synthesizing trans-4-alkylcyclohexyl benzene structure liquid crystal intermediates and monomers

The invention discloses a method for synthesizing trans-4-alkylcyclohexyl benzene structure liquid crystal intermediates and monomers and belongs to the technical field of trans-cyclohexyl benzene liquid crystal. The method comprises the following steps:

LIQUID CRYSTALLINE COMPOUND HAVING DIFLUOROMETHYLENEOXY GROUP, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT

PROBLEM TO BE SOLVED: To provide a liquid crystalline compound having at least one sufficient property in physical properties such as high stability to heat or light, a high clear point (or high maximum temperature), a low minimum temperature of a liquid

NOVEL 5 or 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS SELECTIVE INHIBITORS OF INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES

Disclosed herein are 5 or 8-substituted imidazo [1, 5-a] pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo [1, 5-a] pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo [1, 5-a] pyridines that can be useful for inhibiting indoleamine 2, 3-dioxygenase and/or tryptophane 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.

Liquid crystal compound containing 5-cyclobutyl-1,3-dioxy cyclohexane structure, preparation method and applications thereof

The present invention discloses a liquid crystal compound containing 5-cyclobutyl-1,3-dioxy cyclohexyl and a difluoromethyleneoxy linking group, a preparation method and applications thereof, wherein the compound is represented by a formula I. According t

Fluorinated compounds containing naphthalene structure

PROBLEM TO BE SOLVED: To provide a compound concurrently having a large dielectric anisotropy (Δε), a high clear point (T) and a low viscosity (η), and to provide a liquid crystal composition and a liquid crystal display element including the above compou

Compound having 2-fluorophenyloxymethane structure

There is provided a compound having a good miscibility with another liquid crystal compound and having a combination of a low viscosity (η), high storage stability, and high T?i even after being used to produce a liquid crystal composition. In

ORTHO ESTER DERIVATIVE, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT

The invention is to provide a liquid crystal compound having a large dielectric anisotropy, a high voltage holding ratio and stability to heat, light and so forth, maintaining a nematic phase in a wide temperature range, having a suitable optical anisotropy and an excellent compatibility with other liquid crystal compounds, particularly, to provide a liquid crystal compound having a large dielectric anisotropy. The invention provides compound (1): In the formula, for example, R1 is alkyl and having 1 to 20 carbons; ring A1, ring A2, ring A3, ring A4, ring A5 and ring A6 are independently 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2, Z3, Z4, Z5, Z6 and Z7 are independently a single bond, - (CH2) 2-, -COO-, -OCO-, CF2O-, -OCF2- or -CH=CH-; X1 is fluorine, -CF3 or -OCF3; and Y1 and Y2 are independently hydrogen or fluorine.

COMPOUND HAVING 2-FLUOROPHENYLOXYMETHANE STRUCTURE

The present invention relates to a compound having a 2-fluorophenyloxymethane structure and useful for organic electronic materials and medical and agricultural chemicals, particularly materials for liquid crystal display elements. A problem to be solved