15540-90-6

Basic information

• Product Name: 4,7-Dimethylisatin
• Synonyms: 4,7-Dimethylisatin;1H-indole-2,3-dione, 4,7-dimethyl-;4,7-dimethyl-1H-indole-2,3-dione(SALTDATA: FREE);4,7-diMethylindoline-2,3-dione
• CAS NO: 15540-90-6
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18396
• Mol File: 15540-90-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.25g/cm³
• Refractive Index: 1.586
• CAS DataBase Reference: 4,7-Dimethylisatin(CAS DataBase Reference)
• NIST Chemistry Reference: 4,7-Dimethylisatin(15540-90-6)
• EPA Substance Registry System: 4,7-Dimethylisatin(15540-90-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 15540-90-6(Hazardous Substances Data)

Usage

Uses

4,7-Dimethyl-1H-indole-2,3-dione is used to prepare decamethylanthracene.

InChI:InChI=1/C10H9NO2/c1-5-3-4-6(2)8-7(5)9(12)10(13)11-8/h3-4H,1-2H3,(H,11,12,13)

Upstream product

• 15540-89-3 N-(2,5-dimethylphenyl)-2-hydroxyiminoacetamide 
• 302-17-0 chloral hydrate 
• 95-78-3 2,5-Dimethylaniline 
• 266348-47-4 3-butyl-4-hydroxy-5,8-dimethyl-1H-quinolin-2-one 
• 266348-59-8 3-butyl-3-hydroxy-5,8-dimethyl-1H-quinoline-2,4-dione 
• 266348-60-1 3-hydroxy-5,8-dimethyl-3-phenyl-1H-quinoline-2,4-dione 
• 220462-70-4 3-benzyl-3-hydroxy-5,8-dimethyl-1,2,3,4-tetrahydroquinoline-2,4-dione 
• 79-37-8 oxalyl dichloride 
• 51786-53-9 2,5-dimethylaniline hydrochloride 

Downstream Products

• 59022-71-8 4,7-Dimethyl-2-indolinon 
• 68596-88-3 3,6-dimethylbenzenediazonium 2-carboxylate 
• 63548-78-7 1,4,5,8-tetramethylbiphenylene 
• 15540-91-7 2-amino-3,6-dimethylbenzoic acid 
• 27023-00-3 2-amino-3,6-dimethylbenzoic acid methyl ester 

Relevant articles and documents

Further Studies on Triazinoindoles as Potential Novel Multitarget-Directed Anti-Alzheimer's Agents

The inadequate clinical efficacy of the present anti-Alzheimer's disease (AD) drugs and their low impact on the progression of Alzheimer's disease in patients have revised the research focus from single targets to multitarget-directed ligands. A novel series of substituted triazinoindole derivatives were obtained by introducing various substituents on the indole ring for the development of multitarget-directed ligands as anti-AD agents. The experimental data indicated that some of these compounds exhibited significant anti-AD properties. Among them, 8-(piperidin-1-yl)-N-(6-(pyrrolidin-1-yl)hexyl)-5H-[1,2,4]triazino[5,6-b]indol-3-amine (60), the most potent cholinesterase inhibitor (AChE, IC50 value of 0.32 μM; BuChE, IC50 value of 0.21 μM), was also found to possess significant self-mediated Aβ1-42 aggregation inhibitory activity (54% at 25 μM concentration). Additionally, compound 60 showed strong antioxidant activity. In the PAMPA assay, compound 60 exhibited blood-brain barrier penetrating ability. An acute toxicity study in rats demonstrated no sign of toxicity at doses up to 2000 mg/kg. Furthermore, compound 60 significantly restored the cognitive deficits in the scopolamine-induced mice model and Aβ1-42-induced rat model. In the in silico ADMET prediction studies, the compound satisfied all the parameters of CNS acting drugs. These results highlighted the potential of compound 60 to be a promising multitarget-directed ligand for the development of potential anti-AD drugs.

COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR

The present disclosure is directed to disclosed compounds that modulate, e.g., address underlying defects in cellular processing of CFTR activity.

Synthesis of novel 3-acyloxy-1,3-dihydro-2H-indol-2-ones and isomeric 4- acyl-1,4-dihydro-3,1-benzoxazin-2-ones: Double rearrangement of 3- hydroxyquinoline-2,4(1H,3H)-diones

Substituted 3-hydroxyquinoline-2,4(1H,3H)-diones 3 were transformed into 3-acyloxy-1,3-dihydro-2H-indol-2-ones 4 and isomeric 4-acyl-1,4-dihydro-3,1- benzoxazin-2-ones 5. The influence of the substituents and the reaction conditions on the course of the r