155513-72-7

Basic information

• Product Name: 3-[Bis-(4-chloro-benzoyl)-amino]-pyrazine-2-carboxylic acid methyl ester
• Synonyms: 3-[Bis-(4-chloro-benzoyl)-amino]-pyrazine-2-carboxylic acid methyl ester
• CAS NO: 155513-72-7
• Molecular Weight: 430.247
• Mol File: 155513-72-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[Bis-(4-chloro-benzoyl)-amino]-pyrazine-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[Bis-(4-chloro-benzoyl)-amino]-pyrazine-2-carboxylic acid methyl ester(155513-72-7)
• EPA Substance Registry System: 3-[Bis-(4-chloro-benzoyl)-amino]-pyrazine-2-carboxylic acid methyl ester(155513-72-7)

Safety Data

• Hazardous Substances Data: 155513-72-7(Hazardous Substances Data)

Upstream product

• 16298-03-6 Methyl 3-amino-2-pyrazinecarboxylate 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 155513-80-7 2-(4-Chloro-phenyl)-pyrazino[2,3-d][1,3]oxazin-4-one 
• 92044-73-0 3-(4-chloro-benzoylamino)-pyrazine-2-carboxylic acid methyl ester 

Relevant articles and documents

Dihalogentriphenylphosphoranes in the synthesis of heterocycles, 29. A simple synthesis of pteridin-4-ones, from methyl-3-amino-2-pyrazinecarboxylate and pyrazino[3,1]oxazin-4-ones

Methyl 3-amino-2-pyrazinecarboxylate (3) affords the synthetically useful 3-aroylaminopyrazin-2-carboxylates 5a-f with aroyl chlorides, which are converted with dibromotriphenylphosphorane into 2-arylpyrazino[2,3-d][3,1]oxazin-4-ones 6a-f. Nucleophilic attack at the carbonyl function of these oxazinones results in ring cleaved amides which can be recyclized with dibromotriphenylphosphorane to afford 2-arylpteridin-4-ones 7a-f.