155513-80-7 Usage
General Description
2-(4-Chlorophenyl)-4H-pyrazino[2,3-d][1,3]oxazin-4-one, also known as Vortioxetine, is a chemical compound that is commonly used in the treatment of Major Depressive Disorder (MDD). It belongs to the class of drugs known as serotonin modulators and stimulators (SMSs), which work by increasing the levels of serotonin in the brain. Vortioxetine is a selective serotonin reuptake inhibitor (SSRI) and serotonin receptor modulator, and it is thought to have a multifaceted mechanism of action that involves the modulation of several serotonin receptors. It has been approved by the FDA for the treatment of MDD and has shown promising results in clinical trials for improving symptoms of depression and anxiety. However, like all drugs, Vortioxetine may have potential side effects and should be used under the guidance of a healthcare professional.
Check Digit Verification of cas no
The CAS Registry Mumber 155513-80-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,5,5,1 and 3 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 155513-80:
(8*1)+(7*5)+(6*5)+(5*5)+(4*1)+(3*3)+(2*8)+(1*0)=127
127 % 10 = 7
So 155513-80-7 is a valid CAS Registry Number.
155513-80-7Relevant articles and documents
Dihalogentriphenylphosphoranes in the synthesis of heterocycles, 29. A simple synthesis of pteridin-4-ones, from methyl-3-amino-2-pyrazinecarboxylate and pyrazino[3,1]oxazin-4-ones
Wamhoff,Kroth
, p. 405 - 410 (2007/10/02)
Methyl 3-amino-2-pyrazinecarboxylate (3) affords the synthetically useful 3-aroylaminopyrazin-2-carboxylates 5a-f with aroyl chlorides, which are converted with dibromotriphenylphosphorane into 2-arylpyrazino[2,3-d][3,1]oxazin-4-ones 6a-f. Nucleophilic attack at the carbonyl function of these oxazinones results in ring cleaved amides which can be recyclized with dibromotriphenylphosphorane to afford 2-arylpteridin-4-ones 7a-f.