155527-97-2

Basic information

• Product Name: 4-[4-(dimethylamino)benzylidene]-3-phenyl-5(4H)-isoxazolone
• Synonyms: 4-[4-(dimethylamino)benzylidene]-3-phenyl-5(4H)-isoxazolone;(4Z)-4-[4-(dimethylamino)benzylidene]-3-phenyl-1,2-oxazol-5(4H)-one
• CAS NO: 155527-97-2
• Molecular Formula: C18H16N2O2
• Molecular Weight: 292.33184
• Mol File: 155527-97-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 451.7±55.0 °C(Predicted)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• PKA: 3.69±0.24(Predicted)
• CAS DataBase Reference: 4-[4-(dimethylamino)benzylidene]-3-phenyl-5(4H)-isoxazolone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(dimethylamino)benzylidene]-3-phenyl-5(4H)-isoxazolone(155527-97-2)
• EPA Substance Registry System: 4-[4-(dimethylamino)benzylidene]-3-phenyl-5(4H)-isoxazolone(155527-97-2)

Safety Data

• Hazardous Substances Data: 155527-97-2(Hazardous Substances Data)

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 1076-59-1 3-phenyl-4H-isoxazol-5-one 
• 127916-11-4 ethyl bezoylacetate oxime 
• 889-37-2 N,N-dimethyl-4-((phenylimino)methyl)aniline 
• 23253-51-2 3-phenyl-5-hydroxyisoxazole 
• 7713-79-3 3-phenyl-5-isoxazolone 

Relevant articles and documents

Facile and expedient synthesis of α,β-unsaturated isoxazol-5(4H)-ones under mild conditions

Abstract: It was found that nano-SiO2–H2SO4 was catalyzed by the three-component cyclocondensation of aryl/heteroaryl aldehydes, hydroxylamine hydrochloride, and β-ketoesters toward the synthesis of α,β-unsaturated?isoxazol-5(4H)-ones under green conditions. The reaction yielded the corresponding heterocycles at room temperature in relatively shorter reaction times. It merits mentioning that the mild conditions allow the synthesis of several α,β-unsaturated?isoxazol-5(4H)-ones using this method. In this study, some new derivatives of isoxazolones were also synthesized and characterized. It is efficient, clean, simple, safe, and ecologically friendly. This straightforward method is cost-effective and requires no preparation of reactants. The three-component annulation was performed without using energy sources, for example, heat, ultrasound wave, and microwave irradiation. Graphic abstract: [Figure not available: see fulltext.].

Nano Fe2O3, clinoptilolite and H3PW12O40 as efficient catalysts for solvent-free synthesis of 5(4H)-isoxazolone under microwave irradiation conditions

A quick and solvent-free approach involving the exposure of neat reactants to microwave irradiation in conjunction with the use of clinoptilolite, H3PW12O40 and Fe2O3 nanoparticle catalysts is described. In this work, condensation of hydroxylamine hydroch

The convenient synthesis of 4-arylmethylidene-4,5-dihydro-3-phenylisoxazol- 5-ones

4-Arylmethylidene-4,5-dihydro-3-phenylisoxazol-5-ones were synthesized by the convenient three-component reaction of ethyl benzoylacetate, hydroxylamine and aromatic aldehydes in the presence of pyridine. The target compounds were also obtained by the rea