15561-50-9Relevant academic research and scientific papers
Isoindolone derivatives, their preparation and the pharmaceutical compositions containing them
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, (2008/06/13)
This invention relates to isoindolone derivatives of general formula (I) in which the radicals R are hydrogen atoms or together form a bond, the symbols R'' are phenyl radicals which can be substituted by a halogen atom or a methyl radical in position 2 or 3, X is an oxygen or sulphur atom or a radical N--R 3, R 3 being H, optionally substituted alkyl or dialkylamino, R 1 is optionally substituted phenyl or cyclohexadienyl, naphthyl or a heterocycle and R 2 is H, halogen, OH, alkyl, amionoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxy, alkylthio, acyloxy, carboxyl, optionally substituted alkoxycarbonyl, benzyloxycarbonyl, amino or acylamino, in their (3aR,7aR) forms or in the (3aRS,7aRS) form or their mixtures, and if appropriate their salts where such exist, and their preparation.The new derivatives according to the invention are particularly valuable as antagonists of substance P. STR1
Convenient Preparation of Arylacetic Acids by Tetracarbonylcobaltate Anion Catalysed Carbonylation
Rao, B. Nageswara,Adapa, Srinivas R.,Pardhasaradhi, M.
, p. 84 - 85 (2007/10/02)
Tetracarbonylcobaltate catalyst -, has been prepared in 6 hr by pressure carbonylation of cobalt salt in aq alkaline solution containing cyanide catalyst.Carbonylation of arylchloromethyl derivatives in aq methanolic solutions using this catalyst affords arylacetic acids in good yields.
