3166-95-8

Basic information

• Product Name: 2-(2,6-Dimethoxyphenyl)acetonitrile
• Synonyms: 2-(2,6-Dimethoxyphenyl)acetonitrile
• CAS NO: 3166-95-8
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.2
• Mol File: 3166-95-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(2,6-Dimethoxyphenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,6-Dimethoxyphenyl)acetonitrile(3166-95-8)
• EPA Substance Registry System: 2-(2,6-Dimethoxyphenyl)acetonitrile(3166-95-8)

Safety Data

• Hazardous Substances Data: 3166-95-8(Hazardous Substances Data)

Usage

Physical state

White solid

Common uses

Building block for production of pharmaceuticals and agrochemicals; reagent in organic synthesis

Potential uses

Intermediate in synthesis of biologically active molecules; applications in medicinal chemistry; target for further research and development in drug discovery.

Upstream product

• 16700-55-3 2,6-dimethoxybenzyl alcohol 
• 143-33-9 sodium cyanide 
• 3392-97-0 2,6-dimethoxybenzaldehyde 
• 860189-80-6 3-(2,6-dimethoxy-phenyl)-2-thioxo-propionic acid 
• 127378-31-8 5-(2,6-dimethoxy-benzylidene)-2-thioxo-thiazolidin-4-one 
• 1466-76-8 2-6-dimethoxybenzoic acid 

Downstream Products

• 15561-50-9 2-(2,6-dimethoxyphenyl)acetic acid 

Relevant articles and documents

Structure-Reactivity Studies and Catalytic Effects in the Photosolvolysis of Methoxy-substituted Benzyl Alcohols

The photosolvolysis of several methoxy-, dimethoxy-, and hydroxy-substituted benzyl alcohols has been studied in aqueous solution.The primary photochemical event is photodehydroxylation, to give a benzyl cation intermediate, which can be trapped by added external nucleophiles.The reaction is via the singlet excited state, based on observation of fluorescence quenching by hydronium ion in a complementary manner with acid catalysis of reaction observed for several derivatives.Solvent isotope effects on fluorescence efficiency and reaction for (7) and (8) provide additional support of singlet-state reactivity for these compounds.Dimethoxy-substituted alcohols are more reactive than monosubstituted compounds, with quantum yields of methanolysis of up to 0.31 for the most reactive compound, 2,6-dimethoxybenzyl alcohol (8).Using a kinetic argument, the quantum yields of the primary photodehydroxylation process has been estimated to be 1.0 +/- 0.1 for this compound.The results observed for the dimethoxy-substituted derivatives suggest the existence of additivity of substituent effects in these photodehydroxylation reactions.