15562-06-8

Upstream product

• 1645-75-6 bis(trifluoromethyl)ketimine 
• 71-43-2 benzene 
• 15580-99-1 N-[α,α-Bis-(trifluormethyl)-benzyl]-acetamid 
• 718-64-9 1,1,1,3,3,3-hexafluoro-2-phenylisopropyl alcohol 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 100-47-0 benzonitrile 
• 63780-71-2 trifluoromethanesulfonic acid 2,2,2-trifluoro-1-phenyl-1-trifluoromethyl-ethyl ester 

Downstream Products

• 15581-02-9 m-Brom-α,α-bis-(trifluormethyl)-benzylamin 
• 15580-99-1 N-[α,α-Bis-(trifluormethyl)-benzyl]-acetamid 
• 15581-00-7 N-<α,α-Bis-(trifluormethyl)-nitro-benzyl>-acetamid 
• 15581-01-8 m-Nitro-α,α-bis-(trifluormethyl)-benzylamin 

Relevant academic research and scientific papers

Direct trifluoromethylation of nitriles promoted by tetrabutylammonium bifluoride

The direct trifluoromethylation of nitriles using TMSCF3 is reported. This reaction is promoted by TBABF and provides ,-bistrifluoromethylated amines in moderate to good yields. The reaction conditions are mild and tolerate a range of functional groups. T

Generation of doubly trifluoromethylsubstituted carbocations: Synthesis of α,α-Bis(trifluoromethyl)benzylamines

α,α-Bis(trifluoromethylbenzyl)triflates offer a convenient access to the corresponding amines through S(N)1 type reactions.