15563-48-1

Upstream product

• 39549-05-8 bis(4-nitrobenzyl)disulfide 
• 93282-12-3 N-(chloro(4-nitrophenyl)methylene)-N-methylmethanaminium chloride 
• 100-14-1 4-nitrobenzyl chloride 
• 68-12-2 N,N-dimethyl-formamide 
• 619-73-8 4-nitrobenzyl chloride 
• 506-59-2 N,N-dimethylammonium chloride 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 15184-96-0 4-(N,N-dimethylaminomethyl)nitrobenzene 

Relevant academic research and scientific papers

Transition-Metal-Free, General Construction of Thioamides from Chlorohydrocarbon, Amide and Elemental Sulfur

A general method for one-pot synthesis of thioamides is developed through a three-component reaction involving chlorohydrocarbon, amide and elemental sulfur. Such a strategy does not only avoid residual transition metal in the product but also prevent the generation of C?N coupling by-product. The latter is prone to be generated when alkane halide and amine are present. With the protocol proposed in this work, both alkyl and aryl thioamides can be obtained in moderate to excellent yields with a high tolerance of various functional groups. External oxidants are not required in the reaction. In addition, the reaction mechanisms are addressed using a combination of controlling experiments and quantum chemical calculations.

Method for preparing aryl thioamide compound

The invention discloses a method for preparing an aryl thioamide compound. The method comprises the following steps: under the protection of inert gas, performing stirring to react for 6-12 hours at the reaction temperature of room temperature to 60 DEG C by taking aryl methanol as a substrate, sublimed sulfur as a sulfur source, an alkali metal complex formed by combining alkali metal salt and ligand as a catalyst, alkali as an accelerant, formamide as a solvent and an amine source; and carrying out post-treatment on the reaction product to obtain the aryl thioamide compound. According to theinvention, cheap and easily available aryl methanol is used as a substrate for three-component reaction to prepare the corresponding thioamide compound; the method for preparing the aryl thioamide compound has the technical advantages of simple technological process, high yield, less pollution, safety, environmental protection, greenness, mildness and the like.