155632-07-8Relevant academic research and scientific papers
Selective N1-alkylation of 1,3-dibenzoyluracils: One-pot way to N1-monosubstituted uracil derivatives
Ozerov, Alexander,Novikov, Mikhail,Khandazhinskaya, Anastasiya,Solyev, Pavel
, p. 912 - 922 (2017/06/13)
A new method for synthesis of N1-monosubstituted uracils and 5- and 6-methyluracil derivatives was developed. It consists in the selective N1-deprotection of N1,N3-dibenzoyluracils in anhydrous dimethylformamide in the presence of potassium carbonate at room temperature and subsequent N1-alkylation by allyl, benzyl or phenacyl type halides or by primary alcohols toluenesulfonates conducted one-pot without isolation of the intermediates. Final N3-debenzoylation by aqueous-alcoholic solution of ammonia affords the corresponding N1-monosubstituted uracil derivatives with overall yields of 52-84%.
Research on antiviral agents. 4. Studies on the chemistry of 6-methyl-2-methoxy-4-O-acyloxy and 6-methyl-2,4-di-O-acyloxypyrimidine derivatives as new acylation reagents and inhibitors of uracil DNA glycosylases.
Botta,Saladino,Gentile,Summa,Nicoletti,Verri,Focher,Spadari
, p. 3603 - 3618 (2007/10/02)
The synthesis of 6-methyl-2-methoxy-4-O-acyloxy and 6-methyl-2,4-di-O-acyloxypyrimidine derivatives 2 and 5 along with their properties as acylating agents of amines, alcohols, thiols and α-amino acids have been reported. Interestingly some of the title products revealed an inhibitory activity against the human and herpetic DNA glycosylases.
