155635-65-7Relevant academic research and scientific papers
Design and synthesis of novel heterofused pyrimidine analogues as effective antimicrobial agents
Chandrasekaran, Balakumar,Cherukupalli, Srinivasulu,Karunanidhi, Sivanandhan,Kajee, Afsana,Aleti, Rajeshwar Reddy,Sayyad, Nisar,Kushwaha, Babita,Merugu, Srinivas Reddy,Mlisana, Koleka P.,Karpoormath, Rajshekhar
, p. 246 - 255 (2019)
A total of 66 novel heterofused pyrimidine analogues (pyrazolo[3,4-d]pyrimidine (7-43) and pyrido[2,3-d]pyrimidine (51a-l & 52a-h)) were synthesized by employing suitable methods. The desired structures of all the synthesized compounds were confirmed based on FT-IR, 1H NMR, 13C NMR and HRMS experimental data. Further, 19F NMR and 1H-15N HMBC of the representative compound were presented. All the final compounds were screened for their in vitro antitubercular (Mycobacterium tuberculosis; H37 Rv), antibacterial (S. aureus, B. subtilis, E. coli and P. aeruginosa) and antifungal (C. neoformans, C. albicans and A. niger) activities. Compounds 51d, 51j, 51k, 51l, and 51g displayed good antibacterial and antifungal activity (MIC = 12.5 μg/ml) against bacterial and fungal strains, while moderate inhibition (MIC = 59 μM) was observed for 51l against H37 Rv strain.
Synthesis of novel pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives: Potent and selective adenosine A3 receptor antagonists
Banda, Veeraswamy,Chandrasekaran, Balakumar,Koese, Meryem,Vielmuth, Christin,Mueller, Christa E.,Chavva, Kurumurthy,Gautham, Santhosh Kumar,Pillalamarri, Sambasivarao,Mylavaram, Raghuprasad,Akkinepally, Raghuramarao,Pamulaparthy, Shanthanrao,Banda, Narsaiah
, p. 699 - 707 (2013)
A series of novel pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives 5 was prepared from 2-amino-3-cyano-4-trifluoromethyl-6-phenylpyridine 1 in two steps via formation of iminoether 3 followed by reaction with different aroylhydrazides 4. Represen
Convenient synthesis of?novel 4-substitutedamino-5-trifluoromethyl-2,7-disubstituted pyrido[2,3-d] pyrimidines and?their?antibacterial activity
Ravi Kanth,Venkat Reddy,Hara Kishore,Shanthan Rao,Narsaiah,Surya Narayana Murthy
, p. 1011 - 1016 (2007/10/03)
Novel pyrido[2,3-d]pyrimidines 4 have been synthesised starting from 2-amino-4-trifluoromethyl-6-substituted nicotinonitriles 1 via imine formation, selective amination followed by Dimroth rearrangement. Compound 4 were screened against Gram +ve and -ve b
A novel synthetic route to 2-amino-3-cyano-4-trifluoromethyl-6-substituted pyridines
Narsaiah, B.,Sivaprasad, A.,Venkataratnam, R. V.
, p. 87 - 90 (2007/10/02)
2-Amino-3-cyano-4-trifluoromethyl-6-substituted pyridines have been obtained from 3-cyano-4-trifluoromethyl-6-substituted-2(1H)pyridones via an interesting rearrangement of 2-O-acetamido-3-cyano-4-trifluoromethyl-6-substituted pyridine intermediates.
