15567-95-0

Basic information

• Product Name: N-(2-hydroxyethyl)-N-methylacetamide(SALTDATA: FREE)
• Synonyms: N-(2-hydroxyethyl)-N-methylacetamide(SALTDATA: FREE);N-(2-hydroxyethyl)-N-methyl-ethanamide
• CAS NO: 15567-95-0
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.14634
• Mol File: 15567-95-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 161 °C(Press: 15 Torr)
• Appearance: /
• Density: 1.078 g/cm3
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.24±0.10(Predicted)
• CAS DataBase Reference: N-(2-hydroxyethyl)-N-methylacetamide(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-hydroxyethyl)-N-methylacetamide(SALTDATA: FREE)(15567-95-0)
• EPA Substance Registry System: N-(2-hydroxyethyl)-N-methylacetamide(SALTDATA: FREE)(15567-95-0)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 15567-95-0(Hazardous Substances Data)

Usage

General Description

N-(2-hydroxyethyl)-N-methylacetamide, also known as SALTDATA: FREE, is a chemical compound with the molecular formula C5H11NO2. It is commonly used as a solvent in pharmaceutical and cosmetic products due to its ability to dissolve a wide range of compounds. N-(2-hydroxyethyl)-N-methylacetamide(SALTDATA: FREE) is a colorless liquid with a mild odor, and it is miscible with water, alcohol, and most organic solvents. N-(2-hydroxyethyl)-N-methylacetamide is also used as a stabilizer and as an additive in some cleaning products. It is important to handle this chemical with caution, as it may cause skin and eye irritation.

Upstream product

• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 108-24-7 acetic anhydride 
• 1517-05-1 2-azidoethanol 
• 67-64-1 acetone 
• 4527-98-4 1-acetoxy-2-methylaminoethane hydrochloride 

Downstream Products

• 3195-78-6 N-vinyl-N-methylacetamide 
• 340026-87-1 Diethyl-phosphoramidous acid 2-(acetyl-methyl-amino)-ethyl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 

Relevant articles and documents

Hydrolysis of iminium ethers derived from the reaction of ketones with hydroxy azides: Synthesis of macrocyclic lactams and lactones

The hydrolysis of iminium ether intermediates formed by a nitrogen insertion sequence involving azido alcohols 1 or 2 and ketones was investigated. Ketones containing 6-12-membered rings were surveyed and shown to provide lactams and lactones in good to excellent overall yield. Reactions employing acetone or 5-nonanone gave similar results, generating analogous amides and esters. The relative amounts of lactone vs lactam produced in a given reaction were found to depend on the structures of the reactants and the pH of the basic media used to hydrolyze the iminium ethers. A mechanism accounting for the formation of each product is discussed in terms of ring strain and the protonation state of ortho ester aminal intermediates.

Cycloalkyl and heterocycloalkyl inhibitors as well as preparation method and application thereof

The invention relates to cycloalkyl and heterocycloalkyl inhibitors as well as a preparation method and application thereof. Specifically, the compounds disclosed by the invention have a structure as shown in a formula (I). The invention also discloses a preparation method of the compounds and application of the compounds as KRASG12C inhibitors. The compounds have a good selective inhibition effect on KRASG12C, and have better pharmacodynamic and pharmacokinetic properties and lower toxic and side effects.

Reactions on a Solid Surface. A Simple, Economical, and Efficient Acylation of Alcohols, Amines over Al2O3

Al2O3 brings about a rapid acylation of a range of alcohols and amines with acid chlorides and acid anhydrides, respectively. Amines are easily Boc- and Cbz-protected on reaction with Boc-anhydride and Cbz-Cl, respectively. The acylation of phenols is slow enough to allow chemoselective acylation of alcohols and amines in the presence of phenols.