1556907-01-7Relevant articles and documents
Catalytic Generation of C1 Ammonium Enolates from Halides and CO for Asymmetric Cascade Reactions
Li, Lu-Lu,Ding, Du,Song, Jin,Han, Zhi-Yong,Gong, Liu-Zhu
supporting information, p. 7647 - 7651 (2019/05/15)
A general strategy for the design of asymmetric cascade reactions using readily available halides and carbon monoxide (CO) as substrates is developed. The key is the catalytic generation of C1-ammonium enolates for the subsequent asymmetric cascade reactions through the combination of palladium-catalyzed carbonylation and chiral Lewis base catalysis. Utilizing this strategy, we have established asymmetric formal [1+1+4] and [1+1+2] reactions to afford chiral dihydropyridones and β-lactams with high yields and high enantio- and diastereoselectivities.