155697-64-6

Usage

Structure

Ethyl ester derivative of 1H-Indole-2-carboxylic acid containing a methyl group, a nitro group, and a phenyl group

Usage

Commonly used in the pharmaceutical industry for the synthesis of various drugs and organic compounds

Applications

Potential applications in medicinal chemistry due to its structural features and biological activities

Research and development

May have uses in the creation of new chemical entities and drug candidates

Upstream product

• 28383-65-5 ethyl 2-diazo-3-oxo-3-phenylpropanoate 
• 100-15-2 N-methyl(p-nitroaniline) 
• 23515-78-8 ethyl 5-nitro-3-phenylindole-2-carboxylate 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 

Downstream Products

• 30016-53-6 1-methyl-5-nitro-3-phenyl-1H-indole-2-carboxylic acid 
• 863289-95-6 5-amino-1-methyl-3-phenyl-1H-indole-2-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

One-pot synthesis of N-methylindoles from N-methylanilines and of benzofurans from phenols using transition-metal carbene X-H insertion reactions

Transition-metal carbene X-H insertion reactions (X=N or O) have been employed in the simple conversion of anilines and phenols into indoles and benzofurans, respectively. Thus copper(II) catalyzed N-H insertion reactions of α-diazo-β-ketoesters with N-me

SUBSTITUTED SULFONAMIDE-INDOLE-2-CARBOXYLIC ACID DERIVATIVES AS PAI-1 INHIBITORS

The present invention relates generally to substituted sulfonamide indoles such as substituted sulfonamide indoles, and methods of using them.

SUBSTITUTED PYRROLE-INDOLES AS INHIBITORS OF PAI-1

The present invention relates to substituted pyrrole-indoles of Formula 1 and methods of using them as inhibitors of PAI-1.

Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1

We synthesized and evaluated a novel series of 2-carboxylic acid indole-based inhibitors of plasminogen activator inhibitor-1 (PAI-1). Systematic modification of the N-1 position and the 5-position of the indole scaffold resulted in the identification of several compounds that showed good potency against PAI-1 in the spectrophotometric assay. This potency did not always translate to the antibody assay. Solubility and serum protein binding studies on selected analogs revealed that protein binding might be a factor in the poor correlation between the two assays.

N-alkylation of indole ring using Mitsunobu reaction

Indole rings substituted with two electron withdrawing groups were alkylated on the nitrogen under Mitsunobu reaction conditions.