15575-30-1

Upstream product

• 109-89-7 diethylamine 
• 71-43-2 benzene 
• 10025-67-9 disulfur dichloride 
• 76328-13-7 dibutoxyphosphinothioyl diethylamino trisulfide 
• 42169-95-9 μ-tetrasulfido-1,2-dithio-diphosphoric acid tetra-O-butyl ester 

Downstream Products

• 7783-06-4 hydrogen sulfide 
• 19833-78-4 di-ethylamine hydroiodide 
• 109-89-7 diethylamine 

Relevant academic research and scientific papers

Synthesis and antimicrobial activities of structurally novel S,S′-bis(heterosubstituted) disulfides

The central focus of this study is on the antibacterial and antifungal properties of synthetically produced S,S′-bis(heterosubstituted) disulfides as a means to control the growth of various infection-causing pathogens. Staphylococcus aureus, Francisella tularensis and Candida albicans were each found to be highly susceptible to several of these compounds by agar or broth dilution and Kirby-Bauer diffusion assays. These structurally simple, low molecular weight disulfides have shown promising bioactivities and may serve as leads to the development of effective new antibacterials for pathogenic bacteria such as methicillin-resistant S. aureus and F. tularensis.

ANTIBACTERIAL S-HETEROSUBSTITUTED DISULFIDES

Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.

Design, synthesis, and insecticidal activities of new N-benzoyl-N'-phenyl- N'-sulfenylureas

Aseries of new N'-alkylaminothio,N'-arylaminothio (or dithio), and N',N'-thio (or dithio) derivatives ofN'-benzoyl-N'-phenylureas were designed and synthesized as insect-growth regulators with sulfur dichloride or disulfur dichloride as the original reactant. The new compounds were identified by 1H nuclear magnetic resonancee (NMR) spectroscopy, elemental analysis [or high-resolution mass spectrometry (HRMS)], and single-crystal X-ray diffraction analysis. The X-ray results demonstrated that there exist N-S-N or N-S-S-N bonds in these new compounds. In comparison to the parent N-benzoyl-N'-phenylureas, these derivatives displayed better solubility. The insecticidal activities of the target compounds were evaluated. The results of bioassays showed that compounds 1-24 retained the larvicidal activities of the corresponding benzoylphenylureas (BPUs) and some compounds exhibited better larvicidal activities against oriental armyworm and mosquitoes than the parent BPUs. The larvicidal activities of the selected target compounds 1 and 24 against diamondback moth were better than that of the corresponding parent compounds E and triflumuron.

Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors

Monoglyceride lipase (MGL) inhibition may offer an approach in treating diseases in which higher 2-arachidonoyglycerol activity would be beneficial. We report here the synthesis and pharmacological evaluation of bis(dialkylaminethiocarbonyl)disulfide derivatives as irreversible MGL inhibitors. Inhibition occurs through interactions with MGL C208 and C242 residues, and these derivatives exhibit high inhibition selectivity over fatty acid amide hydrolase, another endocannabinoid-hydrolyzing enzyme. 2009 American Chemical Society.

Method of treating a disease condition caused or exacerbated by an HPV

The invention provides agents and compounds (see (I) and (II)) for use in the treatment or prophylaxis of disease conditions caused or exacerbated by mammalian papillomaviruses, such as human papillomaviruses, as well as methods for the treatment or prevention thereof. In said formulae, R1–R4 and n are as defined herein.

SPECTROSCOPIC PROPERTIES OF N,N'-DITHIOBISAMINES AND THEIR CYCLIC ANALOGUES N,N'-DIALKYLCYCLOTETRASULFUR-1,4-DIIMIDES

A series of N,N'dithiobisamines R2N-S-S-NR2 NR2=N(CH3)2, N(CH2CH3)2, pipreridine, morpholine, N(CH2-C6H5)2 and N,N'-dialkylcyclotetrasulfur-1,4-diimides (RN)2S4R=CH3, C6H11, CH2C6H5 has been prepared and their 1H-NMR, IR, and UV spectra measured.The proton chemical shifts and the ν(S-N) frequency data are consistent with a chain open conformation for R2N-S-S-NR2 and with a cyclic structure for (RN)2S4.From UV spectral data, values of the disulfide dihedral angle were estimated and a strucrture for the compound proposed.

A NEW PREPARATION OF N-ARYL-1-ALKYNESULPHENAMIDES AND THEIR THERMAL REARRANGEMENTS INTO INDOLINE-2-THIONES

Reaction of 1-alkynyl-lithio derivatives with N,N-dialkylaminosulphenyl chlorides 3a,b affords the N,N-dialkyl-1-alkynesulphenamides 4.When treated with stoichiometric amounts of a substituted benzenamine and methanesulfonic (or trifluoroacetic) acid, the sulphenamides 4, are converted into N-aryl-1-alkynesulphenamides 6-20.On heating in benzene, many of these sulphenamides 6-20 undergo -sigmatropic rearrangements followed by cyclisation of the intermediate thioketenes yielding the substituted indoline-2-thiones 21-30.