127562-53-2

Basic information

• Product Name: 4-(1,4-dioxaspiro[4.5]decan-8-yl)morpholine
• Synonyms: 4-(1,4-dioxaspiro[4.5]decan-8-yl)morpholine
• CAS NO: 127562-53-2
• Molecular Formula: C₁₂H₂₁NO₃
• Molecular Weight: 227.30004
• Mol File: 127562-53-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(1,4-dioxaspiro[4.5]decan-8-yl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1,4-dioxaspiro[4.5]decan-8-yl)morpholine(127562-53-2)
• EPA Substance Registry System: 4-(1,4-dioxaspiro[4.5]decan-8-yl)morpholine(127562-53-2)

Safety Data

• Hazardous Substances Data: 127562-53-2(Hazardous Substances Data)

Usage

Uses

4-(1,4-Dioxaspiro[4.5]dec-8-yl)morpholine is an intermediate in the synthesis of 4-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)cyclohex-3-en-1-yl]morpholine (T3026350), a reactant used in the preparation of azaindole derivatives as c-Jun N-terminal kinase inhibitors.

Upstream product

• 110-91-8 morpholine 
• 4746-97-8 cyclohexanedione monoethylene ketal 

Downstream Products

• 155778-83-9 4-(1,4-dioxaspiro<4,5>dec-8-yl)-1-methylpiperazine 
• 1046793-56-9 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl)morpholine 
• 1046793-55-8 4-morpholinocyclohex-1-en-1-yl trifluoromethanesulfonate 
• 139025-94-8 C₁₄H₂₄N₂O₂ 
• 139025-93-7 4-(morpholin-4-yl)cyclohexan-1-one 

Relevant articles and documents

Cobalt-Catalyzed Desymmetric Isomerization of Exocyclic Olefins

Chiral cyclic olefins, 1-methylcyclohexenes, are versatile building blocks for the synthesis of pharmaceuticals and natural products. Despite the prevalence of these structural motifs, the development of efficient synthetic methods remains an unmet challenge. Herein we report a novel desymmetric isomerization of exocyclic olefins using a series of newly designed chiral cobalt catalysts, which enables a straightforward construction of chiral 1-methylcyclohexenes with diversified functionalities. The synthetic utility of this methodology is highlighted by a concise and enantioselective synthesis of a natural product, β-bisabolene. The versatility of the reaction products is further demonstrated by multifarious derivatizations.

COMPOUNDS

Provided are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

THE USE OF 7-AZAINDOLES IN THE INHIBITION OF C-JUN N-TERMINAL KINASE

The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and