155791-18-7Relevant academic research and scientific papers
Solvent-controlled Csp2→O silyl migration: The "one-pot" synthesis of 2,3-disubsituted thiophenes
Devarie-Baez, Nelmi O.,Shuhler, Brian J.,Wang, Hua,Xian, Ming
, p. 4655 - 4658 (2008/03/12)
(Chemical Equation Presented) An effective "one-pot" synthesis of disubstituted thiophene derivatives employing 3-bromo-2-silyl thiophenes has been developed. A solvent-controlled [1,4] Csp2→O silyl migration was involved as the key step in thi
Synthesis and carbonic anhydrase inhibitory activity of 4-substituted 2- thiophenesulfonamides
Holmes,Lee,Wijono,Weinkam,Wheeler,Garst
, p. 1646 - 1651 (2007/10/02)
A series of 4-substituted 2-thiophenesulfonamides was prepared from 3- thiophenecarboxaldehyde using metalation chemistry developed for 3- furaldehyde. Several of these compounds inhibit carbonic anhydrase II in vitro at concentrations of less than 10 nM.
