15580-66-2

Usage

Uses

Used in Pharmaceutical Synthesis:
4-AMINO-1-METHYL-4-PIPERIDINECARBOXYLIC ACID is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of drugs that address a range of medical conditions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-AMINO-1-METHYL-4-PIPERIDINECARBOXYLIC ACID is utilized as a component in the design and creation of new drugs, particularly those intended for the treatment of central nervous system disorders.
Used in Organic Compounds Synthesis:
4-AMINO-1-METHYL-4-PIPERIDINECARBOXYLIC ACID is used as a building block in the synthesis of various organic compounds, highlighting its versatility and importance in organic chemistry.
Used in Chemical Research:
4-AMINO-1-METHYL-4-PIPERIDINECARBOXYLIC ACID is also employed in chemical research to explore new reactions and mechanisms, potentially leading to the discovery of novel applications and advancements in the chemical sciences.

InChI:InChI=1/C7H14N2O2/c1-9-4-2-7(8,3-5-9)6(10)11/h2-5,8H2,1H3,(H,10,11)

Upstream product

• 123194-00-3 4-amino-1-methyl-piperidine 4-carbonitrile 
• 1445-73-4 1-Methyl-4-piperidone 
• 52094-69-6 8-methyl-1,3,8-triazaspiro<4.5>decane-2,4-dione 

Downstream Products

• 228252-34-4 methyl 4-amino-1-methyl-4-piperidinecarboxylate 

Relevant academic research and scientific papers

Design and Synthesis of Fsp3-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

The exploration of innovative chemical space is a critical step in the early phases of drug discovery. Bis-spirocyclic frameworks occur in natural products and other biologically relevant metabolites and show attractive features, such as molecular compactness, structural complexity, and three-dimensional character. A concise approach to the synthesis of bis-spirocyclic-based compound libraries starting from readily available commercial reagents and robust chemical transformations has been developed. A number of novel bis-spirocyclic scaffold examples, as implemented in the European Lead Factory project, is presented.

Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-Sulfonamidoisoquinolinyl)guanidines

1-Isoquinolinylguanidines were previously disclosed as potent and selective inhibitors of urokinase-type plasminogen activator (uPA). Further investigation of this template has revealed that incorporation of a 7-sulfonamide group furnishes a new series of potent and highly selective uPA inhibitors. Potency and selectivity can be achieved with sulfonamides derived from a variety of amines and is further enhanced by the incorporation of sulfonamides derived from amino acids. The binding mode of these 1-isoquinolinylguanidines has been investigated by X-ray cocrystallization studies. uPA inhibitor 26 was selected for further evaluation based on its excellent enzyme potency (Ki 10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). In vitro, compound 26 is able to inhibit exogenous uPA in human chronic wound fluid (IC50 = 0.89 μM). In vivo, in a porcine acute excisional wound model, following topical delivery, compound 26 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. On the basis of this profile, compound 26 (UK-371,804) was selected as a candidate for further preclinical evaluation for the treatment of chronic dermal ulcers.

AZA SPIRO COMPOUNDS ACTING ON THE CHOLINERGIC SYSTEM WITH MUSCARINIC AGONIST ACTIVITY

Compounds useful for treating diseases of the central or peripheral nervous system in mammals have formulae I-XII STR1 wherein ring A or A' together with the spiro-carbon atom constitutes a bridged or unbridged ring containing one or two ring nitrogen atoms; and the other symbols have specified values, subject to certain conditions.

Spiro compounds containing five-membered rings

Compounds useful for treating diseases of the central or peripheral nervous system in mammals have formulae I-XIII: STR1 wherein ring A or A' together with the spiro-carbon atom constitutes a bridged or unbridged ring containing one or two ring nitrogen atoms; and the other symbols have specified values, subject to certain conditions.