52094-69-6

Basic information

• Product Name: 8-triazaspiro(4.5)decane-2,4-dione,8-methyl-3
• Synonyms: 8-triazaspiro(4.5)decane-2,4-dione,8-methyl-3;1,3,8-Triazaspiro(4.5)decane-2,4-dione, 8-methyl-;Brn 0168499
• CAS NO: 52094-69-6
• Molecular Formula: C₈H₁₃N₃O₂
• Molecular Weight: 183.21
• Mol File: 52094-69-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• Refractive Index: 1.575
• CAS DataBase Reference: 8-triazaspiro(4.5)decane-2,4-dione,8-methyl-3(CAS DataBase Reference)
• NIST Chemistry Reference: 8-triazaspiro(4.5)decane-2,4-dione,8-methyl-3(52094-69-6)
• EPA Substance Registry System: 8-triazaspiro(4.5)decane-2,4-dione,8-methyl-3(52094-69-6)

Safety Data

• Hazardous Substances Data: 52094-69-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H13N3O2/c1-11-4-2-8(3-5-11)6(12)9-7(13)10-8/h2-5H2,1H3,(H2,9,10,12,13)

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 151-50-8 potassium cyanide 
• 506-87-6 ammonium carbonate 
• 25012-72-0 ethyl 1-methyl-4-oxo-piperidin-3-carboxylate 

Downstream Products

• 95789-76-7 3-[(Dibenzhydrylamino)-methyl]-8-methyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione 
• 15580-66-2 4-amino-1-methyl-4-piperidinecarboxylic acid 

Relevant articles and documents

Microwave-assisted synthesis of functionalized spirohydantoins as 3-D privileged fragments for scouting the chemical space

Fragment-based drug design has been successfully applied to a large set of proteins, however in order to expand this concept to the most demanding targets, such as protein-protein interactions, it is required to enrich current fragment libraries with new and original 3D privileged fragments. Our goal was to develop a rapid microwave-assisted synthesis of 27 new privileged spirohydantoin fragments. Among them 24 compounds showed a high water solubility. These molecules were plotted according to the normalized principal moments of inertia of their minimized conformers, and most of the compounds were prone to occupy under-populated regions of the triangular plot. Finally we demonstrated that the hydantoin ring can be selectively N-monoalkylated providing the access to rapid functionalization for further elaboration.

ANTIMICROBIAL OXAZOLIDINONE, HYDANTOIN AND IMIDAZOLIDINONE COMPOSITIONS

The present application relates to N-chlorinated oxazolidinone, hydantoin and imidazolidinone compounds of Formula (I): or pharmaceutically acceptable salts thereof, and associated compositions and methods of use as antimicrobial agents.

Central cholinergic agents. III. Synthesis of 2-alkoxy-2,8-diazaspiro[4.5]decane-1,3-diones as muscarinic agonists

A series of 2-alkoxy-2,8-diazaspiro[4.5]decane-1,3-diones and related compounds were synthesized and tested for muscarinic receptor binding affinity using [3H]pirenzepine and [3H]oxotremorine M as ligands. They were also evaluated fo