123194-00-3

Basic information

• Product Name: 4-amino-1-methyl-4-Piperidinecarbonitrile
• Synonyms: 4-amino-1-methyl-4-Piperidinecarbonitrile
• CAS NO: 123194-00-3
• Molecular Formula: C₇H₁₃N₃
• Molecular Weight: 139.19822
• Mol File: 123194-00-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-amino-1-methyl-4-Piperidinecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-1-methyl-4-Piperidinecarbonitrile(123194-00-3)
• EPA Substance Registry System: 4-amino-1-methyl-4-Piperidinecarbonitrile(123194-00-3)

Safety Data

• Hazardous Substances Data: 123194-00-3(Hazardous Substances Data)

Usage

Description

4-amino-1-methyl-4-Piperidinecarbonitrile is a piperidine derivative, a white to off-white solid chemical compound with the molecular formula C7H13N3. It is a versatile building block in organic synthesis, particularly in the development of pharmaceutical compounds and biologically active substances.

Uses

Used in Pharmaceutical Industry:
4-amino-1-methyl-4-Piperidinecarbonitrile is used as an intermediate in the synthesis of various drugs and bioactive molecules. Its unique structure and functional groups make it a valuable component in the production of new pharmaceutical compounds.
Used in Organic Synthesis:
4-amino-1-methyl-4-Piperidinecarbonitrile is used as a versatile building block in organic synthesis, enabling the creation of a wide range of chemical compounds and substances.
It is important to handle 4-amino-1-methyl-4-Piperidinecarbonitrile with caution and follow proper safety protocols, as it may pose health hazards if not handled properly.

Upstream product

• 41838-46-4 4-Amino-1-methylpiperidine 
• 7677-24-9 trimethylsilyl cyanide 
• 1445-73-4 1-Methyl-4-piperidone 
• 773837-37-9 sodium cyanide 
• 7664-41-7 ammonia 
• 151-50-8 potassium cyanide 

Downstream Products

• 15580-66-2 4-amino-1-methyl-4-piperidinecarboxylic acid 
• 228252-34-4 methyl 4-amino-1-methyl-4-piperidinecarboxylate 
• 125889-78-3 4-aminomethyl-1-methyl-piperidin-4-ylamine 
• 625-77-4 N-acetylacetamide 

Relevant articles and documents

Primary α-tertiary amine synthesis via α-C-H functionalization

A quinone-mediated general synthetic platform for the construction of primary α-tertiary amines from abundant primary α-branched amine starting materials is described. This procedure pivots on the efficient in situ generation of reactive ketimine intermediates and subsequent reaction with carbon-centered nucleophiles such as organomagnesium and organolithium reagents, and TMSCN, creating quaternary centers. Furthermore, extension to reverse polarity photoredox catalysis enables reactivity with electrophiles, via a nucleophilic α-amino radical intermediate. This efficient, broadly applicable and scalable amine-to-amine synthetic platform was successfully applied to library and API synthesis and in the functionalization of drug molecules.

Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors

The synthesis and in vitro activities of a series of succinyl-nitrile-based inhibitors of Cathepsin S are described. Several members of this class show nanomolar inhibition of the target enzyme as well as cellular potency. The inhibitors displaying the greatest potency contain N-alkyl substituted piperidine and pyrrolidine rings spiro-fused to the α-carbon of the P1 residue.

Novel succinate derivative compounds useful as cysteine protease inhibitors

Disclosed are novel succinate derivative compounds of the formula (I)/(Ia): wherein R1, R2, R3, R4, R5, R6, R7, X and A are defined herein. The compounds are useful as inhibitors of cysteine proteases. Also disclosed are methods of using and methods of making such compounds.