1558003-74-9Relevant academic research and scientific papers
A straightforward and efficient synthesis of praziquantel enantiomers and their 4′-hydroxy derivatives
Cedillo-Cruz, Alberto,Aguilar, Maria Isabel,Flores-Alamo, Marcos,Palomares-Alonso, Francisca,Jung-Cook, Helgi
, p. 133 - 140 (2014/02/14)
A new method for the synthesis of praziquantel enantiomers via resolution of praziquanamine with (S)-(+)-naproxen was developed. The four 4′-hydroxy derivatives were obtained through each single praziquanamine enantiomer, coupling with cis- and trans-4-(benzyloxy)cyclohexanecarboxylic acids and subsequent hydrogenolysis for the deprotection of the 4′-OH cyclohexane residue. Additionally, the in vitro cysticidal activity of the compounds was tested, finding that (R)-(-)-praziquantel is the eutomer.
