1558008-07-3Relevant academic research and scientific papers
Synthesis and Biological Activity of Short Interfering RNAs Having Several Consecutive Amide Internucleoside Linkages
Kotikam, Venubabu,Viel, Julien A.,Rozners, Eriks
, p. 685 - 690 (2020)
The success of RNA interference (RNAi) as a research tool and potential therapeutic approach has reinvigorated interest in chemical modifications of RNA. Replacement of the negatively charged phosphates with neutral amides may be expected to improve bioav
Synthesis, biophysical studies and RNA interference activity of RNA having three consecutive amide linkages
Tanui, Paul,Kennedy, Scott D.,Lunstad, Benjamin D.,Haas, Amanda,Leake, Devin,Rozners, Eriks
supporting information, p. 1207 - 1210 (2014/03/21)
RNA sequences having up to three consecutive internal amide linkages were synthesized and studied using UV and NMR spectroscopy. The amide modifications did not interfere with normal base-pairing and A-type RNA conformation. Three consecutive amides were well tolerated in the passenger strand of siRNA and caused little change in RNAi activity.
