15584-08-4

Upstream product

• 15485-64-0 2-(4-chlorophenyl)-1-(2,4-dihydroxyphenyl)ethan-1-one 
• 2258-42-6 formyl acetic anhydride 
• 15485-68-4 α-(4-chlorophenyl)-2,4,6-trihydroxyacetophenone 
• 68-12-2 N,N-dimethyl-formamide 
• 108-46-3 recorcinol 
• 108-73-6 3,5-dihydroxyphenol 
• 140-53-4 p-chlorobenzyl cyanide 

Downstream Products

• 121076-27-5 4'-chloro-5-hydroxy-7-(tetra-O-acetyl-β-D-glucopyranosyloxy)isoflavone 
• 1445711-48-7 5-methoxy-4-oxo-3-(4-chlorophenyl)-4H-chromen-7-yl dimethylcarbamate 
• 1445711-58-9 7-hydroxy-5-methoxy-3-(4-chlorophenyl)-4H-chromen-4-one 
• 1445711-91-0 7-hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-5-methoxy-3-(4-chlorophenyl)-4H-chromen-4-one 
• 1445712-00-4 7-hydroxy-5-methoxy-8-(morpholin-4-ylmethyl)-3-(4-chlorophenyl)-4H-chromen-4-one 
• 1445711-85-2 7-hydroxy-5-methoxy-8-(piperidin-1-ylmethyl)-3-(4-chlorophenyl)-4H-chromen-4-one 
• 1445711-37-4 5-hydroxy-4-oxo-3-(4-chlorophenyl)-4H-chromen-7-yl dimethylcarbamate 

Relevant academic research and scientific papers

Synthesis and aminomethylation of 7-hydroxy-5-methoxyisoflavones

A synthetic method for 7-hydroxy-5-methoxyisoflavones starting from 5,7-dihydroxyisoflavones was developed. Dimethylcarbamoylchloride was proposed for protection of the 7-hydroxy group. Aminomethylation of the synthesized 7-hydroxy-5-methoxyisoflavones by formaldehyde aminals was studied.

COMPOUNDS FOR IMMUNOPOTENTIATION

Methods of stimulating an immune response and treating patients responsive thereto with 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-diones, staurosporine analogs, derivatized pyridazines, chromen-4-ones, indolinones, quinazolines, nucleoside analogs, and other small molecules are disclosed.

Mixed Anhydride of Acetic and Formic Acids in the Synthesis of Chromones. 2. Synthesis of 3-Arylchromones

A study was carried out on the reaction of α-substituted 2-hydroxyacetophenones eith the mixed anhydride of acetic and formic acids in the presence of bases of different strength.Chromones containing a conjugated electron-withdrawing substituent at C(3) are formed in close to quantitative yield in the presence of triethylamine.The preparation of chromones containing an unconjugated substituent under these conditions is recommended only for 5-hydroxychromones.

ACETOFORMIC ANHYDRIDE IN THE SYNTHESIS OF CHROMONES. 1. SYNTHESIS OF 3-HETARYLCHROMONES

It was shown that the reaction of α-(het)aryl-2,4-dihydroxy- and 2,4,6-trihydroxyacetophenones with acetoformic anhydride catalyzed by sodium formate is an effective method for the preparation of chromones containing a heteroaromatic residue at the 3-position.The yield of the chromone and the rate of the reaction increase with increase in the ?-deficiency of this residue or in the presence of a hydroxy group in the 6-position of the starting acetophenone.In the last case the method is also applicable to the preparation of the difficulty available 3-aryl-5,7-dihydroxychromones.Chromones with a nitrogen-containing residue are formed without the use of any catalyst.

EFFECTIVE SYNTHESIS OF 7-HYDROXYISOFLAVONE O-GLUCOSIDES

An effective procedure for condensing acetobromoglucose with 2,4-dihydroxy phenyl benzyl ketones has been developed.The 2-hydroxy-4-(β-D-tetra-O-acetylglucopyranosyloxy)phenyl benzyl ketones synthesized with yields of 47-69percent have been converted under the action of ethyl orthoformate in pyridine solution into 7-hydroxyisoflavone O-glukosides and these have also been obtained by the glycosylation of 7-hydroxyisoflavone.The advantages and disadvantages of the alternative pathways of the synthesis of 7-hydroxyisoflavone O-glykosides are discussed.