15485-68-4

Basic information

• Product Name: 2-(4-Chlorophenyl)-1-(2,4,6-trihydroxyphenyl)ethanone
• Synonyms: Acetophenone,2-(p-chlorophenyl)-2',4',6'-trihydroxy- (8CI); a-(4-Chlorophenyl)-2,4,6-trihydroxyacetophenone
• CAS NO: 15485-68-4
• Molecular Formula: C₁₄H₁₁ClO₄
• Molecular Weight: 278.69
• Mol File: 15485-68-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 224–225°C
• Appearance: /
• CAS DataBase Reference: 2-(4-Chlorophenyl)-1-(2,4,6-trihydroxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Chlorophenyl)-1-(2,4,6-trihydroxyphenyl)ethanone(15485-68-4)
• EPA Substance Registry System: 2-(4-Chlorophenyl)-1-(2,4,6-trihydroxyphenyl)ethanone(15485-68-4)

Safety Data

• Hazardous Substances Data: 15485-68-4(Hazardous Substances Data)

Usage

Preparation

Obtained by reaction of p-chlorophenylacetonitrile with phloroglucinol (Hoesch reaction).

Upstream product

• 1878-66-6 4-chlorophenylacetic Acid 
• 108-73-6 3,5-dihydroxyphenol 
• 140-53-4 p-chlorobenzyl cyanide 

Downstream Products

• 15584-08-4 5,7-dihydroxy-3-(4-chlorophenyl)-4H-chromen-4-one 
• 1445711-37-4 5-hydroxy-4-oxo-3-(4-chlorophenyl)-4H-chromen-7-yl dimethylcarbamate 
• 1445711-48-7 5-methoxy-4-oxo-3-(4-chlorophenyl)-4H-chromen-7-yl dimethylcarbamate 
• 1445711-58-9 7-hydroxy-5-methoxy-3-(4-chlorophenyl)-4H-chromen-4-one 
• 1445711-91-0 7-hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-5-methoxy-3-(4-chlorophenyl)-4H-chromen-4-one 
• 1445712-00-4 7-hydroxy-5-methoxy-8-(morpholin-4-ylmethyl)-3-(4-chlorophenyl)-4H-chromen-4-one 
• 1445711-85-2 7-hydroxy-5-methoxy-8-(piperidin-1-ylmethyl)-3-(4-chlorophenyl)-4H-chromen-4-one 
• 121076-27-5 4'-chloro-5-hydroxy-7-(tetra-O-acetyl-β-D-glucopyranosyloxy)isoflavone 
• 85602-22-8 4'-chloro-2,4,6-trihydroxy-3-(3-methyl-but-2-enyl)-deoxybenzoin 

Relevant articles and documents

Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3Kα H1047R mutant inhibitors

Phosphatidylinositol 3-kinase α (PI3Kα) is one of the most attractive therapeutic targets for cancer treatment. As our continuing endeavor to discover isoform and/or mutant selective class of PI3K inhibitors, herein we report the optimization of a structu

Synthesis and aminomethylation of 7-hydroxy-5-methoxyisoflavones

A synthetic method for 7-hydroxy-5-methoxyisoflavones starting from 5,7-dihydroxyisoflavones was developed. Dimethylcarbamoylchloride was proposed for protection of the 7-hydroxy group. Aminomethylation of the synthesized 7-hydroxy-5-methoxyisoflavones by formaldehyde aminals was studied.