15485-68-4

Usage

Preparation

Obtained by reaction of p-chlorophenylacetonitrile with phloroglucinol (Hoesch reaction).

Upstream product

• 108-73-6 3,5-dihydroxyphenol 
• 140-53-4 p-chlorobenzyl cyanide 
• 1878-66-6 4-chlorophenylacetic Acid 

Downstream Products

• 85602-22-8 4'-chloro-2,4,6-trihydroxy-3-(3-methyl-but-2-enyl)-deoxybenzoin 
• 15584-08-4 5,7-dihydroxy-3-(4-chlorophenyl)-4H-chromen-4-one 
• 1445711-37-4 5-hydroxy-4-oxo-3-(4-chlorophenyl)-4H-chromen-7-yl dimethylcarbamate 
• 1445711-48-7 5-methoxy-4-oxo-3-(4-chlorophenyl)-4H-chromen-7-yl dimethylcarbamate 
• 1445711-58-9 7-hydroxy-5-methoxy-3-(4-chlorophenyl)-4H-chromen-4-one 
• 1445711-91-0 7-hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-5-methoxy-3-(4-chlorophenyl)-4H-chromen-4-one 
• 1445712-00-4 7-hydroxy-5-methoxy-8-(morpholin-4-ylmethyl)-3-(4-chlorophenyl)-4H-chromen-4-one 
• 1445711-85-2 7-hydroxy-5-methoxy-8-(piperidin-1-ylmethyl)-3-(4-chlorophenyl)-4H-chromen-4-one 
• 121076-27-5 4'-chloro-5-hydroxy-7-(tetra-O-acetyl-β-D-glucopyranosyloxy)isoflavone 

Relevant academic research and scientific papers

Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3Kα H1047R mutant inhibitors

Phosphatidylinositol 3-kinase α (PI3Kα) is one of the most attractive therapeutic targets for cancer treatment. As our continuing endeavor to discover isoform and/or mutant selective class of PI3K inhibitors, herein we report the optimization of a structu

A Direct Synthesis of 2-(ω-Carboxyalkyl)isoflavones from ortho-Hydroxylated Deoxybenzoins

As part of a program focused on the development of new antineoplastic agents based on scaffolds found in natural products, we explored the isoflavone family as potential enzyme inhibitors. We required biotin-modified isoflavones to identify potential biological targets, and we selected the C-2 position in isoflavones as an attachment site for an alkyl group bearing a terminal carboxylic acid to which we could attach a biotin derivative. The base-catalyzed condensation of 2,4-dihydroxy-substituted deoxybenzoins with cyclic anhydrides mediated by a combination of triethylamine and 1,8-diazabicyclo[5.4.0]undec-7-ene led to an efficient synthesis of the desired 2-(ω-carboxyalkyl)isoflavones with functional groups at C-5, 6 and 7 and with various substituents in the C-3 phenyl group.

Synthesis and aminomethylation of 7-hydroxy-5-methoxyisoflavones

A synthetic method for 7-hydroxy-5-methoxyisoflavones starting from 5,7-dihydroxyisoflavones was developed. Dimethylcarbamoylchloride was proposed for protection of the 7-hydroxy group. Aminomethylation of the synthesized 7-hydroxy-5-methoxyisoflavones by formaldehyde aminals was studied.