15584-10-8

Basic information

• Product Name: 3-(4-fluorophenyl)-7-hydroxy-4h-1-benzopyran-4-on
• Synonyms: 3-(4-fluorophenyl)-7-hydroxy-4h-1-benzopyran-4-on;3-(4-fluorophenyl)-7-hydroxy-4h-1-benzopyran-4-one;7-Hydroxy-3-(4-fluorophenyl)-4H-1-benzopyran-4-one
• CAS NO: 15584-10-8
• Molecular Formula: C₁₅H₉FO₃
• Molecular Weight: 256.2285632
• Mol File: 15584-10-8.mol
• Article Data: 14

Chemical Properties

• Melting Point: 235-236 °C
• Boiling Point: 443.6°Cat760mmHg
• Flash Point: 222.1°C
• Appearance: /
• Density: 1.408g/cm³
• Vapor Pressure: 1.76E-08mmHg at 25°C
• Refractive Index: 1.646
• PKA: 6.88±0.20(Predicted)
• CAS DataBase Reference: 3-(4-fluorophenyl)-7-hydroxy-4h-1-benzopyran-4-on(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-fluorophenyl)-7-hydroxy-4h-1-benzopyran-4-on(15584-10-8)
• EPA Substance Registry System: 3-(4-fluorophenyl)-7-hydroxy-4h-1-benzopyran-4-on(15584-10-8)

Safety Data

• Hazardous Substances Data: 15584-10-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H9FO3/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,17H

Upstream product

• 15485-70-8 4'-fluoro-2,4-dihydroxydeoxybenzoin 
• 124-63-0 methanesulfonyl chloride 
• 68-12-2 N,N-dimethyl-formamide 
• 459-22-3 4-fluorophenylacetonitrile 
• 108-46-3 recorcinol 
• 405-50-5 p-Fluorophenylacetic acid 
• 111841-07-7 2-hydroxy-4-(tetrahydropyran-2-yloxy)acetophenone 
• 935659-63-5 3-iodo-7-((tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 1124174-57-7 4'-fluoro-7-(tetrahydropyran-2-yloxy)isoflavone 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 1160861-89-1 7-decanoyloxy-3-(4'-fluorophenyl)-4H-1-benzopyran-4-one 
• 1010935-15-5 C₂₀H₁₈FNO₃ 
• 1010880-76-8 C₂₀H₁₈FNO₃ 
• 1010905-73-3 C₂₁H₂₀FNO₄ 
• 433330-11-1 3-(2,4-dihydroxyphenyl)-4-(4-fluorophenyl)-1H-pyrazole 

Relevant articles and documents

Novel isoflavone derivative, preparation method therefor and medicinal use of novel isoflavone derivative

The invention relates to the field of pharmaceutical chemistry, relates to an isoflavone derivative, a preparation method therefor and medicinal use of the novel isoflavone derivative and particularlyrelates to isoflavone derivatives represented by a general formula (I) shown in the description, preparation methods therefor, pharmaceutical compositions containing these compounds and medicinal useof the isoflavone derivatives and the pharmaceutical compositions, particularly use of drugs for preventing or treating hyperlipidemia, type II diabetes, atherosclerosis and non-alcoholic fatty hepatitis.

Novel daidzein analogs and their in vitro anti-influenza activities

A series of novel isoflavonoids were synthesized based on structural modifications of daidzein, an active ingredient of traditional Chinese medicine (TCM) and evaluated for their anti-influenza activity, in vitro, against H1N1 Tamiflu-resistant (H1N1 TR) virus in the MDCK cell line. Among them, 4-oxo-4H-1-benzopyran-8-carbaldehydes 11a-11g were most promising, and they demonstrated better activities and selectivities comparable to those the reference ribarivin, a nucleoside antiviral agent. 3-(4-Bromophenyl)-7-hydroxy-4-oxo-4H-1-benzopyran-8-carboxaldehyde (11c) displayed the best inhibitory activity (EC50, 29.0 μM) and selectivity index (SI>10.3). Analysis of the structure￡activity relationships (SAR) indicated that both the non-naturally-occurring Br-substituted B-ring and appropriate CHO and OH groups on the A-ring might be critical for the activity and selectivity against H1N1 TR influenza viruses.

New para-substituted non-symmetric isoflavones for their fast photo-switching ability: Synthesis and their liquid crystal characterization

The first example of non-symmetric isoflavone-based fast photo-switchable liquid crystals with different functional groups at the terminal position were synthesized and characterized. Polarizing optical microscopy study revealed that the compounds showed least ordered nematic phase. Optical photo switching study exhibited very fast photoisomerization effect in solution. The E-Z and Z-E conversion occurred around 3-5 s and 40-700 s respectively. This is also the first example of para-substituted non-symmetric isoflavone liquid crystals exhibiting very fast photo switching property in solution. Argument based on non-symmetrical behaviour might be the reason for the observed behaviour.