155884-28-9

Basic information

• Product Name: 4-Oxazolecarboxylicacid,4,5-dihydro-2-methyl-,methylester(9CI)
• Synonyms: 4-Oxazolecarboxylicacid,4,5-dihydro-2-methyl-,methylester(9CI);4,5-Dihydro-2-methyl-1,3-oxazole-4-carboxylic acid methyl ester;Ac-Thr-OMe-4,5-dihydrooxazole;methyl 2-methyl-4,5-dihydrooxazole-4-carboxylate
• CAS NO: 155884-28-9
• Molecular Formula: C₆H₉NO₃
• Molecular Weight: 143.14
• Product Categories: CARBOXYLICESTER
• Mol File: 155884-28-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 40 °C
• Boiling Point: 181.0±33.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• PKA: 3.70±0.70(Predicted)
• CAS DataBase Reference: 4-Oxazolecarboxylicacid,4,5-dihydro-2-methyl-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Oxazolecarboxylicacid,4,5-dihydro-2-methyl-,methylester(9CI)(155884-28-9)
• EPA Substance Registry System: 4-Oxazolecarboxylicacid,4,5-dihydro-2-methyl-,methylester(9CI)(155884-28-9)

Safety Data

• Hazardous Substances Data: 155884-28-9(Hazardous Substances Data)

Usage

Description

4-Oxazolecarboxylic acid, 4,5-dihydro-2-methyl-, methylester(9CI) is a methyl ester derivative of 4,5-dihydro-2-methyl-4-oxazolecarboxylic acid, characterized by its white solid appearance and a molecular formula of C7H9NO3. With a molecular weight of 155.15 g/mol, this compound plays a significant role in organic synthesis and pharmaceutical research, serving as a building block for the creation of various compounds. Its potential biological activities and uses in the pharmaceutical industry are areas of ongoing exploration, necessitating further research and testing to fully comprehend its properties and applications.

Uses

Used in Organic Synthesis:
4-Oxazolecarboxylic acid, 4,5-dihydro-2-methyl-, methylester(9CI) is used as a key intermediate in organic synthesis for the preparation of a wide range of chemical compounds. Its unique structure allows for versatile reactions, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-Oxazolecarboxylic acid, 4,5-dihydro-2-methyl-, methylester(9CI) is utilized as a building block for the development of new drugs. Its incorporation into drug molecules can potentially enhance their pharmacological properties, such as potency, selectivity, and bioavailability. 4-Oxazolecarboxylicacid,4,5-dihydro-2-methyl-,methylester(9CI)'s potential biological activities are currently under investigation, with the aim of identifying its therapeutic potential and applications in various disease conditions.
Used in Drug Development:
4-Oxazolecarboxylic acid, 4,5-dihydro-2-methyl-, methylester(9CI) is employed in drug development as a starting material for the synthesis of novel drug candidates. Its unique chemical properties and reactivity make it a promising candidate for the design of innovative therapeutic agents with improved efficacy and safety profiles.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-Oxazolecarboxylic acid, 4,5-dihydro-2-methyl-, methylester(9CI) is used as a structural motif in the design of new chemical entities. Its presence in a molecule can influence the overall pharmacokinetic and pharmacodynamic properties of a drug, making it an important component in the development of next-generation therapeutics.
Overall, 4-Oxazolecarboxylic acid, 4,5-dihydro-2-methyl-, methylester(9CI) is a versatile compound with applications spanning across various industries, particularly in organic synthesis and pharmaceutical research. Its potential uses in drug development and medicinal chemistry highlight its importance in the discovery and design of new therapeutic agents. Further research and testing are essential to unlock its full potential and contribute to the advancement of the pharmaceutical industry.

Upstream product

• 2208-07-3 ethyl acetimidate hydrochloride 
• 5874-57-7 R-(-)-serine methyl ester hydrochloride 
• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 
• 2104-89-4 Ser-OMe 
• 1000-84-6 O-ethyl acetimidate 
• 14777-27-6 methyl acetimidate hydrochloride 
• 5619-04-5 methyl 2-amino-3-hydroxypropanoate hydrochloride 

Downstream Products

• 23012-17-1 2-methyl-1,3-oxazol-4-carboxylic acid 
• 657389-99-6 4-(bromomethyl)-2-methyl-1,3-oxazole 
• 141567-53-5 4-hydroxymethyl-2-methyloxazole 
• 113732-84-6 2-methyl-1,3-oxazole-4-carbaldehyde 
• 7652-46-2 2-acetylamino-3-mercapto-propionic acid methyl ester 
• 85806-67-3 2-methyl-oxazole-4-carboxylic acid methyl ester 

Relevant articles and documents

The synthesis of novel disorazoles

Big little brother: The simplified disorazole analogue 1 exhibits its cytotoxic activity at low nanomolar concentrations and provides selectivities not observed for the parent natural product.

PYRROLE ANTIFUNGAL AGENTS

The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

Large-scale preparation of 2-methyloxazole-4-carboxaldehyde

The large-scale preparation of 2-methyloxazole-4-carboxaldehyde presents a significant challenge due to the physical characteristics of the molecule. A method for the preparation of 10-kg batches of 2-methyloxazole-4-carboxaldehyde is described. The key reaction is the reduction of the corresponding N-methoxy-N-methyl amide using lithium aluminium hydride, followed by workup and isolation by crystallization.