155943-46-7Relevant articles and documents
General access to C-centered radicals: Combining a bioinspired photocatalyst with boronic acids in aqueous media
Bloom, Steven,Chilamari, Maheshwerreddy,Immel, Jacob R.
, p. 12727 - 12737 (2020/11/18)
Carbon-centered radicals are indispensable building blocks for modern synthetic chemistry. In recent years, visible light photoredox catalysis has become a promising avenue to access C-centered radicals from a broad array of latent functional groups, including boronic acids. Herein, we present an aqueous protocol wherein water features a starring role to help transform aliphatic, aromatic, and heteroaromatic boronic acids to C-centered radicals with a bioinspired flavin photocatalyst. These radicals are used to deliver a diverse pool of alkylated products, including three pharmaceutically relevant compounds, via open-shell conjugate addition to disparate Michael acceptors. The mechanism of the reaction is investigated by computational studies, deuterium labeling, radical-trapping experiments, and spectroscopic analysis.
New dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme: Rational design, bioavailability, and pharmacological responses in experimental hypertension
Fournie-Zaluski,Coric,Turcaud,Rousselet,Gonzalez,Barbe,Pham,Jullian,Michel,Roques
, p. 1070 - 1083 (2007/10/02)
In the treatment of cardiovascular diseases, it could be of therapeutic interest to associate the hypotensive effects resulting from the inhibition of angiotensin II formation, ensured by endothelial angiotensin-converting enzyme (ACE), with the diuretic
