155997-93-6

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 

Downstream Products

• 256946-24-4 5-hydroxy-1,7-bis-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-heptan-3-one 
• 256946-35-7 5-hydroxy-1-phenyl-7-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-heptan-3-one 
• 256946-22-2 3-[4'-(tetrahydropyran-2'-yloxy)phenyl]propionaldehyde 
• 83161-96-0 (+/-)-5-hydroxy-7-(4'-hydroxyphenyl)-1-phenyl-3-heptanone 
• 41137-85-3 (+/-)-5-hydroxy-1,7-bis-(4'-hydroxyphenyl)-3-heptanone 
• 256946-28-8 3-(4'-pyranyloxyphenyl)propanol 
• 155997-95-8 3-(4-tetrahydropyran-2-yloxyphenyl)propionic acid 

Relevant academic research and scientific papers

Synthesis and digestibility inhibition of diarylheptanoids: Structure- activity relationship

(±)-5-Hydroxy-1,7-bis-(4'-hydroxyphenyl)-3-heptanone (2a), (±)5- hydroxyl-1-(4'-hydroxyphenyl)-7-phenyl-3-heptanone (2b), (±)-5-hydroxy-7- (4'-hydroxyphenyl)-1-phenyl-3-heptanone (2c), and (±)-5-hydroxy-1,7- bis(phenyl)-3-heptanone (2d) have been synthesized to study the structure- activity relationship regarding digestibility inhibition in vitro in cow rumen fluid. The activities were compared with the activity of chiral (S)-2a and its glucoside platyphylloside (1), isolated from Betula pendula. Compound 2a was slightly less active, 2b and 2c were more active, and 2d was less active than (S)-2a and platyphylloside.

Protecting group for carboxyl function: Mild and facile cleavage of 2- cyanoethyl ester under non-hydrolytic conditions

The use of the 2-cyanoethyl group for carboxyl-protection is described. This group was readily introduced by esterification using ethylene cyanohydrin and the deprotection was carried out under mild conditions using tetrabutylammonium fluoride in dimethylformamide-tetrahydrofuran.