256946-22-2

Upstream product

• 155997-93-6 methyl 3-(4-tetrahydropyran-2-yloxyphenyl)propionate 
• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 
• 110-87-2 3,4-dihydro-2H-pyran 
• 256946-28-8 3-(4'-pyranyloxyphenyl)propanol 

Downstream Products

• 256946-35-7 5-hydroxy-1-phenyl-7-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-heptan-3-one 
• 83161-96-0 (+/-)-5-hydroxy-7-(4'-hydroxyphenyl)-1-phenyl-3-heptanone 
• 41137-85-3 (+/-)-5-hydroxy-1,7-bis-(4'-hydroxyphenyl)-3-heptanone 

Relevant academic research and scientific papers

7-PHENYL-ISOQUINOLINE-5-SULFONYLAMINO DERIVATIVES AS INHIBITORS OF AKT (PROTEINKINASE B)

The present invention relates to compounds Formula (I) as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.

Synthesis and digestibility inhibition of diarylheptanoids: Structure- activity relationship

(±)-5-Hydroxy-1,7-bis-(4'-hydroxyphenyl)-3-heptanone (2a), (±)5- hydroxyl-1-(4'-hydroxyphenyl)-7-phenyl-3-heptanone (2b), (±)-5-hydroxy-7- (4'-hydroxyphenyl)-1-phenyl-3-heptanone (2c), and (±)-5-hydroxy-1,7- bis(phenyl)-3-heptanone (2d) have been synthesized to study the structure- activity relationship regarding digestibility inhibition in vitro in cow rumen fluid. The activities were compared with the activity of chiral (S)-2a and its glucoside platyphylloside (1), isolated from Betula pendula. Compound 2a was slightly less active, 2b and 2c were more active, and 2d was less active than (S)-2a and platyphylloside.