83161-96-0

Upstream product

• 2550-26-7 4-Phenyl-2-butanone 
• 93559-08-1 (2-Phenethyl-[1,3]dioxolan-2-yl)-acetonitrile 
• 72134-60-2 (2-Phenethyl-[1,3]dioxolan-2-yl)-acetaldehyde 
• 256946-22-2 3-[4'-(tetrahydropyran-2'-yloxy)phenyl]propionaldehyde 
• 155997-93-6 methyl 3-(4-tetrahydropyran-2-yloxyphenyl)propionate 
• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 
• 93559-16-1 4-(4-Benzyloxy-phenyl)-1-(2-phenethyl-[1,3]dioxolan-2-yl)-butan-2-ol 
• 256946-28-8 3-(4'-pyranyloxyphenyl)propanol 

Relevant academic research and scientific papers

Antiviral activity of diarylheptanoid stereoisomers against respiratory syncytial virus in vitro and in vivo

We previously showed that (5S)-5-hydroxy-7-(4-hydroxyphenyl)-1-phenylhept- 3-one (AO-0011) and (5S)-5-methoxy-1,7-diphenylhept-3-one (AO-0016) isolated from Alpinia officinarum exhibited stronger anti-influenza virus activity and anti-respiratory syncytia

Synthesis and digestibility inhibition of diarylheptanoids: Structure- activity relationship

(±)-5-Hydroxy-1,7-bis-(4'-hydroxyphenyl)-3-heptanone (2a), (±)5- hydroxyl-1-(4'-hydroxyphenyl)-7-phenyl-3-heptanone (2b), (±)-5-hydroxy-7- (4'-hydroxyphenyl)-1-phenyl-3-heptanone (2c), and (±)-5-hydroxy-1,7- bis(phenyl)-3-heptanone (2d) have been synthesized to study the structure- activity relationship regarding digestibility inhibition in vitro in cow rumen fluid. The activities were compared with the activity of chiral (S)-2a and its glucoside platyphylloside (1), isolated from Betula pendula. Compound 2a was slightly less active, 2b and 2c were more active, and 2d was less active than (S)-2a and platyphylloside.

NEW METHODS AND REAGENTS IN ORGANIC SYNTHESIS. 47. A GENERAL, EFFICIENT, AND CONVENIENT SYNTHESIS OF DIARYLHEPTANOIDS

An efficient synthesis of physiologically interesting diarylheptanoids has been carried out through direct C-acylation using diethyl phosphorocyanidate (DEPC) followed by Grignard reactions with aldehydes.Keywords - diarylheptanoid; C-acylation; diethyl p