15600-32-5

Upstream product

• 75-44-5 phosgene 
• 98-85-1 1-Phenylethanol 
• 503-38-8 trichloromethyl chloroformate 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 108-88-3 toluene 

Downstream Products

• 13371-24-9 triphenyl-(1-phenyl-ethyl)-phosphonium; chloride 
• 265659-68-5 α-methylbenzyl azidoformate 
• 1017848-55-3 2-(4-methoxyphenyl)-4-methyloxazol-5-yl 1-phenylethyl carbonate 
• 1017848-58-6 4-benyl-2-(4-methoxyphenyl)oxazol-5-yl 1-phenylethyl carbonate 
• 2605-18-7 1-methoxy-4-(1-phenylethyl)benzene 
• 141036-94-4 benzyl (α-methylbenzyl) carbonate 
• 672-65-1 (1-chloroethyl)benzene 

Relevant academic research and scientific papers

Deoxygenative cross-electrophile coupling of benzyl chloroformates with aryl iodides

This work describes Ni-catalyzed cross-electrophile coupling of benzyl chloroformate derivatives with aryl iodides that generates a wide range of diaryl methane products. The mild reaction conditions merit the C-O bond radical fragmentation of benzyl chloroformates via halide abstraction or a single electron reduction by a Ni catalyst. This work offers a new substrate type for cross-electrophile couplings.

NOVEL DITHIOLOPYRROLONES AND THEIR THERAPEUTICAL APPLICATIONS

The present invention provides novel dithiolopyrrolone compounds and their salts, which promote production of white blood cells and are useful as prevention and treatments for microbial infections such as HIV infection and blood disorders such as neutropenia and other related diseases. The present invention also provides therapeutic compositions comprising particularly useful types of dithiolopyrrolones, the salts thereof, and methods and use in the manufacture of a medication for treatment of diseases.

A facile synthesis of azidoformate via chloroformate

This work synthesized chloroformates by slowly adding alcohols into a suspension of trichloromethyl chloroformate, instead of phosgene, along with activated charcoal in tetrahydrofuran. This chloroformylation yielded chloroformates in near quantitative yield. The subsequent reaction between chloroformates and sodium azide in dry acetone produced azidoformates in a high yield.

SYNTHESES DE CARBONATES ET CARBAMATES BENZYLIQUES ET ALLYLIQUES

Different methods for the preparation of carbonates and carbamates derived from 1-phenylethyl, 2-cyclohexenyl and 1-methyl-2-propenyl are described.These conmpounds have been synthesized by the reactions of alcohols, phenols or amines with chloroformiates, imidazolocarbonates or corresponding mixed p-nitrophenylcarbonates. It is shown that these reactions can also be used for the introduction of 1-phenylethyloxycarbonyl - (I), 2-cyclohexenyloxycarbonyl - (II) and 1-methyl-2-propenyloxycarbonyl - (III) groups into alcohols, phenols and amines for the protection of hydroxyls and amino-groups.