156001-73-9

Upstream product

• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 
• 18278-34-7 4-hydroxy-2-methoxybenzaldehyde 
• 17763-80-3 para-nitrophenyl triflate 
• 358-23-6 trifluoromethylsulfonic anhydride 

Downstream Products

• 289889-77-6 2-methoxy-4-(3-phenylpropyl)benzaldehyde 
• 343603-82-7 3-methoxy-[1,1'-biphenyl]-4-carbaldehyde 
• 457628-23-8 2-hydroxy-4-(trifluoromethanesulfonyloxy)benzaldehyde 
• 370884-66-5 2-methoxy-4-(5-phenyl-1-pentynyl)benzaldehyde 
• 943153-30-8 trifluoro-methanesulfonic acid 3-methoxy-4-[(2-methyl-propane-2-sulfinylamino)-methyl]-phenyl ester 
• 635679-15-1 2-hydroxy-4-[5-(4-methyl-2,5-bis-trimethylsilanylethynyl-phenyl)-thiophen-2-yl]-benzaldehyde 
• 635679-10-6 4-[5-(2,5-diethynyl-4-methyl-phenyl)-thiophen-2-yl]-2-triisopropylsilanyloxy-benzaldehyde 
• 635679-16-2 4-[5-(2,5-diethynyl-4-methyl-phenyl)-thiophen-2-yl]-2-hydroxy-benzaldehyde 

Relevant academic research and scientific papers

4-Aryl-substituted 2,5-dimethoxyphenethylamines: Synthesis and serotonin 5-HT2A receptor affinities

A series of novel ligands for the serotonin 5-HT2A/C receptor subtype bearing the 2-phenylethylamine pharmacophore was synthesized and assayed for its 5-HT2A receptor binding affinity. As the 4′-arylsubstituted 2-(2,5-dimethoxyphenyl

Compounds with medicinal effects due to interaction with the glucocorticoid receptor

The invention provides for compounds having the structure according to the formula I

ERβ ligands. Part 2: Synthesis and structure-activity relationships of a series of 4-hydroxy-biphenyl-carbaldehyde oxime derivatives

A series of biphenyl carbaldehyde oximes (6) was prepared and shown to have significant selectivity for the estrogen receptor-β (ERβ). The exploitation of the oxime moiety as a hydrogen bond donating group, which mimicked the C-ring of genistein makes these compounds unique. Molecular modeling studies showed the oxime moiety hydrogen bonding to the histidine residue, which was supported by the structure-activity relationships. The most potent compounds in this study had IC50 values in a radioligand binding assay of between 8-35nM. Among the most selective compounds were 6i and 6s (49- and 31-fold ERβ selective, respectively).

HYDROXY-BIPHENYL-CARBALDEHYDE OXIME DERIVATIVES AND THEIR USE AS ESTROGENIC AGENTS

This invention provides estrogen receptor modulators having the structure formula (I): wherein R1 to R6 and R8 are as defined in the specification; or a pharmaceutically acceptable salt thereof.

A Fluorescent Self-Amplifying Wavelength-Responsive Sensory Polymer for Fluoride Ions

A glowing response: Novel fluoride-selective sensors, utilizing fluoride-induced lactonization to highly fluorescent coumarin derivatives, are reported. The incorporation of this sensory system into a conjugated polymer amplifies the fluorescence response

1-[2-methoxy-5-(3-phenylpropyl)]-2-aminopropane unexpectedly shows 5-HT2A serotonin receptor affinity and antagonist character

Certain phenylethylamines, such as 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane (DOB; 1a), are high-affinity 5-HT2 agonists. Previous structure - affinity studies have concluded that both the 2,5-dimethoxy substitution pattern and the nature of substituents at the 4-position are important determinants of high affinity. We recently demonstrated that replacement of the bromo group of DOB with a 3-(phenyl)propyl substituent results in retention of affinity and that, counter to established structure - affinity relationships, the 2,5-dimethoxy substitution pattern is no longer a requirement for the binding. The present investigation extends these findings by examining a series of analogues, 3, lacking a 5-methoxy group. It was additionally found that shifting the phenylalkyl substituent from the 4- to the 5-position (e.g., 4i) also results in retention of affinity. For example, 1-(2-methoxy-5-(3-phenylpropyl)-2-aminopropane (6; the α-methyl derivative of 4i) binds at 5-HT2A receptors with high affinity (Ki = 13 nM) and possesses 5-HT2A antagonist character. Thus, not only is the 2,5-dimethoxy substitution pattern not a requirement for the binding of certain phenylethylamines at 5-HT2A receptors, the presence of a 4-position substituent (previously thought to serve as a modulator of affinity of DOB-like agents) is also not required. Striking differences in the 5-HT2A binding requirements of the present compounds as compared to DOB-like agents suggest multiple substituent-dependent modes of binding.

1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT(2A) partial agonists

Phenylalkylamines such as 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane (DOB; 1a) and its corresponding iodo derivative DOI (2) are commonly used 5-HT2 serotonin agonists. Previous studies have established that the 2,5-dimethoxy substitution p

Trisubstituted biphenyls

Antihypertensive and antiatherosclerotic trisubstituted biphenyls of the formula STR1 in which R1 represents a carboxyl radical or represents a C1 -C8 -alkoxycarbonyl radical, R2 represents straight-chain or bra