156002-64-1

Basic information

• Product Name: Heterocycles
• Synonyms: Heterocycles;7-(Trifluoromethyl)quinolin-4-ol;Methyl 2-(tetrahydro-2H-pyran-4-yl)acetate;4-Bromo-2-mercaptobenzothiazole;2-Furoic thioamide;2-Pyrazinecarboxylic Hydrazide;3-Isopropyl-piperazine-2,5-dione;3-Thiophene-carboxylic Hydrazide
• CAS NO: 156002-64-1
• Molecular Formula: C₈H₁₄O₃
• Molecular Weight: 158.2
• Product Categories: blocks;Carboxes;Heterocycles;Heterocyclic Compound;ADVANCED CHEMICALS
• Mol File: 156002-64-1.mol

Chemical Properties

• Boiling Point: 208.5±13.0 °C(Predicted)
• Appearance: /
• Density: 1.020±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Heterocycles(CAS DataBase Reference)
• NIST Chemistry Reference: Heterocycles(156002-64-1)
• EPA Substance Registry System: Heterocycles(156002-64-1)

Safety Data

• Hazardous Substances Data: 156002-64-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Heterocycles are used as active pharmaceutical ingredients for the development of various drugs due to their diverse chemical properties and potential to interact with biological targets.
Used in Agricultural Chemicals:
In the agricultural sector, heterocycles are utilized as pesticides and herbicides, leveraging their reactivity and stability to control pests and weeds effectively.
Used in Dye Industry:
Heterocycles are employed in the production of dyes, where their unique structures contribute to the color and stability of the dyes in various applications.
Used in Fragrance Industry:
They are also used in the creation of fragrances, where their distinct chemical properties help in developing a wide range of scents for different uses.

Upstream product

• 67-56-1 methanol 
• 85064-61-5 2-(tetrahydro-2H-pyran-4-yl)acetic acid 
• 138302-49-5 methyl 2-(dihydro-2H-pyran-4-(3H)-ylidene)acetate 
• 130312-00-4 ethyl tetrahydro-4H-pyran-4-ylideneacetate 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 103260-44-2 ethyl tetrahydropyran-4-acetate 

Downstream Products

• 815618-35-0 (R)-4-benzyl-3-(2-(tetrahydro-2H-pyran-4-yl)acetyl)oxazolidin-2-one 
• 634908-68-2 N-(4-fluorobenzyl)-4-phenyl-3-(tetrahydro-2H-pyran-4-yl)butan-1-amine 
• 634908-64-8 N-(4-chlorobenzyl)-4-phenyl-3-(tetrahydro-2H-pyran-4-yl)butan-1-amine 

Relevant articles and documents

1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS

The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyridinones which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.

Synthesis and activity of putative small-molecule inhibitors of the F-box protein SKP2

The tetrahydropyran 4-(((3-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-4-phenylbutyl)amino)methyl)-N,N-dimethylaniline was reported to disrupt the SCFSKP2 E3 ligase complex. Efficient syntheses of this tetrahydropyran derivative and analogues, including the des-dimethyl derivative 4-(((3-(tetrahydro-2H-pyran-4-yl)-4-phenylbutyl)amino)methyl)-N,N-dimethylaniline, are described. The enantiomers of the des-dimethyl compound were obtained using Evans' chiral auxiliaries. Structure-activity relationships for these tetrahydropyrans and analogues have been determined by measurement of growth-inhibitory activities in HeLa cells, which indicated a non-specific mechanism of action that correlates with inhibitor lipophilicity. However, preliminary data with (R)-and (S)-4-(((3-(tetrahydro-2H-pyran-4-yl)-4-phenylbutyl)amino)methyl)-N,N-dimethylaniline showed enantioselective inhibition of the degradation of p27 in a cell-based assay that acts as a reporter of SKP2 activity.

Heterocyclic compounds as P2X7 ion channel blockers

The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: 1 wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer''s disease, etc.

HYDROXAMATE SULFONAMIDES AS CD23 SHEDDING INHIBITORS

A class of piperidine and related heterocyclic derivatives, C-substituted by a substituted aryl or heteroaryl moiety, and N-substituted by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.

HYDROXAMATE SULFONAMIDES AS CD23 SHEDDING INHIBITORS

A class of piperazine and related heterocyclic derivatives, substituted at the 4-position by a substituted aryl or heteroaryl moiety, and at the 1-position by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.

Tetrahydropyran Esters as New Attractants for Cockroaches

Twenty four tetrahydropyran esters were synthesised and tested as attractants toward Blattella germanica and Supella longipalpa in the laboratory by using the choice-chamber method.In general, carboxylates were superior to propionates and acetates.Among the 2-, 3-, or 4-substituted esters, substitution at the 4-position was better than at the other two positions.These results are explained in terms of the receptor model proposed earlier by others.