85064-61-5

Basic information

• Product Name: Tetrahydropyranyl-4-acetic acid
• Synonyms: 2-(TETRAHYDRO-2H-PYRAN-4-YL)ACETIC ACID;(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID;TETRAHYDROPYRANYL-4-ACETIC ACID;TETRAHYDRO-2H-PYRAN-4-YLACETIC ACID;Tetrahydro-2H-pyran-4-ylacetic acid 97%;Tetrahydropyran-4-acetic acid;Tetrahydro-4-pyranacetic acid;Tetrahydropyran-4-acetic acid ,97%
• CAS NO: 85064-61-5
• Molecular Formula: C₇H₁₂O₃
• Molecular Weight: 144.16838
• EINECS: 210-361-8
• Product Categories: blocks;Carboxes;Heterocycles;Heterocycles series;Carboxylic Acids;Pyrans, Piperidines &Piperazines;Carboxylic Acids;Pyrans, Piperidines & Piperazines
• Mol File: 85064-61-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 48-50°C
• Boiling Point: 285.1 °C at 760 mmHg
• Flash Point: 119.2 °C
• Appearance: white to light yellow crystal powder
• Density: 1.111 g/cm³
• Vapor Pressure: 0.000738mmHg at 25°C
• Storage Temp.: Keep Cold
• PKA: 4.60±0.10(Predicted)
• CAS DataBase Reference: Tetrahydropyranyl-4-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrahydropyranyl-4-acetic acid(85064-61-5)
• EPA Substance Registry System: Tetrahydropyranyl-4-acetic acid(85064-61-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41-37/38
• Safety Statements: 26-36/37/39-22-39
• RIDADR: 1759
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 85064-61-5(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

InChI:InChI=1/C7H12O3/c8-7(9)5-6-1-3-10-4-2-6/h6H,1-5H2,(H,8,9)/p-1

Upstream product

• 14390-06-8 tetrahydropyran-4-yl-malonic acid 
• 138302-49-5 methyl 2-(dihydro-2H-pyran-4-(3H)-ylidene)acetate 
• 156002-64-1 methyl 2-(tetrahydro-2H-pyran-4-yl)acetate 
• 854697-63-5 tetrahydropyran-4-yl-malonic acid diethyl ester 
• 125552-89-8 4-(bromomethyl)tetrahydro-2H-pyran 
• 14774-37-9 (tetrahydro-2H-pyran-4-yl)methanol 
• 2081-44-9 Tetrahydro-pyran-4-ol 
• 130312-00-4 ethyl tetrahydro-4H-pyran-4-ylideneacetate 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 103260-44-2 ethyl tetrahydropyran-4-acetate 
• 850429-50-4 2-(tetrahydro-2H-pyran-4-yl)acetonitrile 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 

Relevant articles and documents

Synthesis and activity of putative small-molecule inhibitors of the F-box protein SKP2

The tetrahydropyran 4-(((3-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-4-phenylbutyl)amino)methyl)-N,N-dimethylaniline was reported to disrupt the SCFSKP2 E3 ligase complex. Efficient syntheses of this tetrahydropyran derivative and analogues, including the des-dimethyl derivative 4-(((3-(tetrahydro-2H-pyran-4-yl)-4-phenylbutyl)amino)methyl)-N,N-dimethylaniline, are described. The enantiomers of the des-dimethyl compound were obtained using Evans' chiral auxiliaries. Structure-activity relationships for these tetrahydropyrans and analogues have been determined by measurement of growth-inhibitory activities in HeLa cells, which indicated a non-specific mechanism of action that correlates with inhibitor lipophilicity. However, preliminary data with (R)-and (S)-4-(((3-(tetrahydro-2H-pyran-4-yl)-4-phenylbutyl)amino)methyl)-N,N-dimethylaniline showed enantioselective inhibition of the degradation of p27 in a cell-based assay that acts as a reporter of SKP2 activity.

COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

HYDROXAMATE SULFONAMIDES AS CD23 SHEDDING INHIBITORS

A class of piperidine and related heterocyclic derivatives, C-substituted by a substituted aryl or heteroaryl moiety, and N-substituted by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.