156025-77-3Relevant academic research and scientific papers
A Facile Preparation of N-(Isopropoxyalkyl) Amides by Generation and Trapping of N-Acyliminium Ions from Ionization-Rearrangement Reactions of N-Triflyloxy Amides
Hoffman, Robert V.,Nayyar, Naresh K.
, p. 3530 - 3539 (2007/10/02)
A series of hydroxamic acids were converted to N-triflyloxy amides which were heated in 2-propanol to give N-(1-isopropoxyalkyl) amides in high yields.The method is simple, direct, and extremely tolerant of structural diversity both in the N-acyl group, a
Generation of N-Acyl Iminium Ions from Ionization-Rearrangement Reactions of N-Triflyloxy Amides
Hoffman, Robert V.,Nayyar, Naresh K.,Shankweiler, Jean M.,Klinekole III, Bruce W.
, p. 3231 - 3234 (2007/10/02)
N-Triflyloxy amides undergo ionization in refluxing isopropanol to give N-acyliminium ions which can be trapped by addition of allyltrimethylsilane to the reaction mixture.Alternatively they can be converted to N-(isopropoxy)alkyl amides and then back to
