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156032-14-3

156032-14-3

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156032-14-3 Usage

Uses

2-Amino-2-methyl-butyric acid methyl ester, HCl

Check Digit Verification of cas no

The CAS Registry Mumber 156032-14-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,6,0,3 and 2 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 156032-14:
(8*1)+(7*5)+(6*6)+(5*0)+(4*3)+(3*2)+(2*1)+(1*4)=103
103 % 10 = 3
So 156032-14-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H13NO2.ClH/c1-4-6(2,7)5(8)9-3;/h4,7H2,1-3H3;1H

156032-14-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 2-amino-2-methylbutanoate,hydrochloride

1.2 Other means of identification

Product number -
Other names 2-AMINO-2-METHYL-BUTYRIC ACID METHYL ESTER HYDROCHLORIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:156032-14-3 SDS

156032-14-3Synthetic route

Z-Aib-OH
15030-72-5

Z-Aib-OH

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

Z-Aib-DL-Iva-OMe
156032-15-4

Z-Aib-DL-Iva-OMe

Conditions
ConditionsYield
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide for 48h; Ambient temperature;93%
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

2-nitrobenzyl chloride
610-14-0

2-nitrobenzyl chloride

methyl 2-methyl-2-(2-nitrobenzamido)butanoate
1444223-97-5

methyl 2-methyl-2-(2-nitrobenzamido)butanoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 4h;83%
4-chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6

4-chloro-3-(trifluoromethyl)phenyl isocyanate

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

2-<3-(4-Chlor-α,α,α-trifluor-m-tolyl)ureido>-2-methylbuttersaeuremethylester

2-<3-(4-Chlor-α,α,α-trifluor-m-tolyl)ureido>-2-methylbuttersaeuremethylester

Conditions
ConditionsYield
With sodium carbonate In tetrahydrofuran for 18h; Heating;1.8 g
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

2-methyl-2-{[1-(2-phenoxy-ethoxy)-naphthalene-2-carbonyl]-amino}-butyric acid methyl ester
1000922-63-3

2-methyl-2-{[1-(2-phenoxy-ethoxy)-naphthalene-2-carbonyl]-amino}-butyric acid methyl ester

Conditions
ConditionsYield
Stage #1: 1-(2-phenoxy-ethoxy)-naphthalene-2-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: (±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 16h;
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

HCl*H-Aib-DL-Iva-OMe

HCl*H-Aib-DL-Iva-OMe

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 93 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 48 h / Ambient temperature
2: 98 percent / 1 N aq. HCl, H2 / 10percent Pd/C / methanol
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

Z-Val-Aib-DL-Iva-OMe
156032-17-6

Z-Val-Aib-DL-Iva-OMe

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 93 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 48 h / Ambient temperature
2: 98 percent / 1 N aq. HCl, H2 / 10percent Pd/C / methanol
3: 75 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 48 h / Ambient temperature
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

HCl*H-Val-Aib-DL-Iva-OMe

HCl*H-Val-Aib-DL-Iva-OMe

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 93 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 48 h / Ambient temperature
2: 98 percent / 1 N aq. HCl, H2 / 10percent Pd/C / methanol
3: 75 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 48 h / Ambient temperature
4: 93 percent / 1 N aq. HCl, H2 / 10percent Pd/C / methanol
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

Z-Pro-Val-Aib-DL-Iva-OMe
156032-19-8

Z-Pro-Val-Aib-DL-Iva-OMe

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 93 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 48 h / Ambient temperature
2: 98 percent / 1 N aq. HCl, H2 / 10percent Pd/C / methanol
3: 75 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 48 h / Ambient temperature
4: 93 percent / 1 N aq. HCl, H2 / 10percent Pd/C / methanol
5: 79 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 48 h / Ambient temperature
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

Z-Pro-Val-Aib-DL-Iva-OH
156032-20-1

Z-Pro-Val-Aib-DL-Iva-OH

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 93 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 48 h / Ambient temperature
2: 98 percent / 1 N aq. HCl, H2 / 10percent Pd/C / methanol
3: 75 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 48 h / Ambient temperature
4: 93 percent / 1 N aq. HCl, H2 / 10percent Pd/C / methanol
5: 79 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 48 h / Ambient temperature
6: 77 percent / NaOH / methanol
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

H-Pro-Val-Aib-DL-Iva-Gln-Gln-Lol

H-Pro-Val-Aib-DL-Iva-Gln-Gln-Lol

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 93 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 48 h / Ambient temperature
2: 98 percent / 1 N aq. HCl, H2 / 10percent Pd/C / methanol
3: 75 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 48 h / Ambient temperature
4: 93 percent / 1 N aq. HCl, H2 / 10percent Pd/C / methanol
5: 79 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 48 h / Ambient temperature
6: 77 percent / NaOH / methanol
7: 61 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 24 h / Ambient temperature
8: 94.3 percent / H2 / 10percent Pd/C / methanol
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

Z-Pro-Val-Aib-DL-Iva-Gln-Gln-Lol

Z-Pro-Val-Aib-DL-Iva-Gln-Gln-Lol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 93 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 48 h / Ambient temperature
2: 98 percent / 1 N aq. HCl, H2 / 10percent Pd/C / methanol
3: 75 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 48 h / Ambient temperature
4: 93 percent / 1 N aq. HCl, H2 / 10percent Pd/C / methanol
5: 79 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 48 h / Ambient temperature
6: 77 percent / NaOH / methanol
7: 61 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), Et3N / dimethylformamide / 24 h / Ambient temperature
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

3-(4-Chlor-α,α,α-trifluor-m-tolyl)-5-ethyl-5-methylhydantoin
92668-60-5

3-(4-Chlor-α,α,α-trifluor-m-tolyl)-5-ethyl-5-methylhydantoin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.8 g / Na2CO3 / tetrahydrofuran / 18 h / Heating
2: HCl (6N) / acetone / 1.5 h / Heating
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

C18H19N3O4S
1431140-96-3

C18H19N3O4S

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr
4: acetic acid / 1 h / 150 - 200 °C
5: chloroform / 20 h / 65 °C
6: pyridine / 16 h / 70 °C
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

C18H17F2N3O4S
1431141-05-7

C18H17F2N3O4S

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr
4: acetic acid / 1 h / 150 - 200 °C
5: chloroform / 20 h / 65 °C
6: pyridine / 16 h / 70 °C
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

C18H17F2N3O4S
1431141-21-7

C18H17F2N3O4S

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr
4: acetic acid / 1 h / 150 - 200 °C
5: chiral ReproSil column chromatography / methanol / Resolution of racemate
6: chloroform / 65 °C
7: pyridine / dichloromethane / 20 °C
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

C19H21N3O4S
1431141-12-6

C19H21N3O4S

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr
4: acetic acid / 1 h / 150 - 200 °C
5: chloroform / 20 h / 65 °C
6: pyridine / 16 h / 70 °C
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

C19H21N3O4S
1431140-97-4

C19H21N3O4S

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr
4: acetic acid / 1 h / 150 - 200 °C
5: chloroform / 20 h / 65 °C
6: pyridine / 16 h / 70 °C
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

C18H25N3O4S
1431140-98-5

C18H25N3O4S

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr
4: acetic acid / 1 h / 150 - 200 °C
5: chloroform / 20 h / 65 °C
6: pyridine / 16 h / 70 °C
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

3-ethyl-3-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
1431141-33-1

3-ethyl-3-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr
4: acetic acid / 1 h / 150 - 200 °C
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

C18H18ClN3O4S
1431140-99-6

C18H18ClN3O4S

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr
4: acetic acid / 1 h / 150 - 200 °C
5: chloroform / 20 h / 65 °C
6: pyridine / 16 h / 70 °C
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

C18H18ClN3O4S
1431141-00-2

C18H18ClN3O4S

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr
4: acetic acid / 1 h / 150 - 200 °C
5: chloroform / 20 h / 65 °C
6: pyridine / 16 h / 70 °C
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

C18H18ClN3O4S
1431141-01-3

C18H18ClN3O4S

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr
4: acetic acid / 1 h / 150 - 200 °C
5: chloroform / 20 h / 65 °C
6: pyridine / 16 h / 70 °C
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

C19H18F3N3O4S
1431141-02-4

C19H18F3N3O4S

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr
4: acetic acid / 1 h / 150 - 200 °C
5: chloroform / 20 h / 65 °C
6: pyridine / 16 h / 70 °C
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

C12H13ClN2O4S
1431141-36-4

C12H13ClN2O4S

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr
4: acetic acid / 1 h / 150 - 200 °C
5: chloroform / 20 h / 65 °C
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

C19H21N3O5S
1431141-03-5

C19H21N3O5S

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr
4: acetic acid / 1 h / 150 - 200 °C
5: chloroform / 20 h / 65 °C
6: pyridine / 16 h / 70 °C
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

2-methyl-2-(2-nitrobenzamido)butanoic acid
1444223-90-8

2-methyl-2-(2-nitrobenzamido)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

2-(2-aminobenzamido)-2-methylbutanoic acid
1444223-76-0

2-(2-aminobenzamido)-2-methylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

A

(S)-(-)-3-ethyl-3-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
1431141-39-7

(S)-(-)-3-ethyl-3-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

B

(R)-(+)-3-ethyl-3-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
1431141-40-0

(R)-(+)-3-ethyl-3-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr
4: acetic acid / 1 h / 150 - 200 °C
5: chiral ReproSil column chromatography / methanol / Resolution of racemate
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

S-(-)-3-ethyl-3-methyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-sulfonyl chloride
1431141-41-1

S-(-)-3-ethyl-3-methyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr
4: acetic acid / 1 h / 150 - 200 °C
5: chiral ReproSil column chromatography / methanol / Resolution of racemate
6: chloroform / 65 °C
View Scheme
(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride
156032-14-3

(±)-2-methyl-2-aminobutanoic acid methyl ester hydrochloride

C19H19F2N3O5S
1431141-04-6

C19H19F2N3O5S

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol
3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 760.05 Torr
4: acetic acid / 1 h / 150 - 200 °C
5: chloroform / 20 h / 65 °C
6: pyridine / 16 h / 70 °C
View Scheme

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