1561-06-4

Basic information

• Product Name: 1-O-Tetradecylglycerin
• Synonyms: 1-O-Tetradecylglycerin;3-Myristyloxy-1,2-propanediol;3-Tetradecyloxy-1,2-propanediol
• CAS NO: 1561-06-4
• Molecular Formula: C₁₇H₃₆O₃
• Molecular Weight: 288.4659
• Mol File: 1561-06-4.mol
• Article Data: 12

Chemical Properties

• Melting Point: 55 °C
• Boiling Point: 418.3°Cat760mmHg
• Flash Point: 206.8°C
• Appearance: /
• Density: 0.927g/cm³
• Vapor Pressure: 9.5E-09mmHg at 25°C
• Refractive Index: 1.462
• PKA: 13.68±0.20(Predicted)
• CAS DataBase Reference: 1-O-Tetradecylglycerin(CAS DataBase Reference)
• NIST Chemistry Reference: 1-O-Tetradecylglycerin(1561-06-4)
• EPA Substance Registry System: 1-O-Tetradecylglycerin(1561-06-4)

Safety Data

• Hazardous Substances Data: 1561-06-4(Hazardous Substances Data)

Usage

Synthetic chemical compound

1-O-Tetradecylglycerin is a man-made compound derived from glycerin.

Glycerin derivative

It is created by attaching a tetradecyl group to glycerin, resulting in a modified version of the original compound.

Fatty acid ester

The attachment of the tetradecyl group to glycerin forms a fatty acid ester, which is a type of ester compound with a long hydrocarbon chain.

Emollient

It helps to soften and smooth the skin, providing a soothing and nourishing effect.

Common use in cosmetic industry

1-O-Tetradecylglycerin is widely used in personal care products, such as moisturizers, lotions, and creams.

Effective moisturization

The compound is known for its ability to effectively hydrate and soften the skin, making it a popular choice in skincare formulations.

Non-greasy and lightweight texture

1-O-Tetradecylglycerin has a smooth, non-greasy feel, making it suitable for facial and body skincare products.

Generally considered safe

Despite being synthetic, 1-O-Tetradecylglycerin is considered safe for topical use and has a low potential for causing skin irritation.

InChI:InChI=1/C17H36O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-20-16-17(19)15-18/h17-19H,2-16H2,1H3

Upstream product

• 112-71-0 1-Bromotetradecane 
• 100-79-8 (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol 
• 102364-25-0 Allyl tetradecyl ether 
• 2425-54-9 myristyl chloride 
• 931-40-8 4-hydroxymethyl-1,3-dioxolan-2-one 
• 112-72-1 1-Tetradecanol 
• 544-63-8 n-tetradecanoic acid 
• 56-81-5 glycerol 
• 10564-42-8 1-(2,3-bis-trimethylsilanyloxy-propoxy)-2-(toluene-4-sulfonyloxy)-tetradecane 
• 10564-40-6 α-(2-p-Tosyloxy-tetradecyl)-glycerin-ether 
• 1191-50-0 sodium tetradecyl sulphate 
• 13879-87-3 4-(n-tetradecyloxymethyl)-2,2-dimethyl-1,3-dioxolane 
• 10588-90-6 3-tetradec-1-en-t-yloxy-propane-1,2-diol 
• 17677-14-4 1-chloro-3-tetradecyloxy-propan-2-ol 

Downstream Products

• 1561-58-6 1-myristyl-3-trityl glycerol 
• 213738-37-5 dibenzyl 3-O-tetradecyl-rac-glycero-1-phosphate 
• 76-84-6 triphenylmethyl alcohol 
• 97488-41-0 2-octadecyloxy-1-tetradecyloxy-3-trityloxy-propane 
• 97084-55-4 1,2-bis-tetradecyloxy-3-trityloxy-propane 
• 1561-55-3 (±)-2,3-bis-tetradecyloxypropan-1-ol 
• 1561-56-4 1-Myristyloxy-2-lauryloxy-glycerin 
• 1290143-57-5 1-[(4-methoxyphenyl)(diphenyl)methoxy]-3-(tetradecyloxy)propan-2-ol 

Relevant articles and documents

Synthesis of alkyl-glycerolipids standards for gas chromatography analysis: Application for chimera and shark liver oils

Natural O-alkyl-glycerolipids, also known as alkyl-ether-lipids (AEL), feature a long fatty alkyl chain linked to the glycerol unit by an ether bond. AEL are ubiquitously found in different tissues but, are abundant in shark liver oil, breast milk, red blood cells, blood plasma, and bone marrow. Only a few AEL are commercially available, while many others with saturated or mono-unsaturated alkyl chains of variable length are not available. These compounds are, however, necessary as standards for analytical methods. Here, we investigated different reported procedures and we adapted some of them to prepare a series of 1-O-alkyl-glycerols featuring mainly saturated alkyl chains of various lengths (14:0, 16:0, 17:0, 19:0, 20:0, 22:0) and two monounsaturated chains (16:1, 18:1). All of these standards were fully characterized by NMR and GC-MS. Finally, we used these standards to identify the AEL subtypes in shark and chimera liver oils. The distribution of the identified AEL were: 14:0 (20–24%), 16:0 (42–54%) and 18:1 (6–16%) and, to a lesser extent, (0.2–2%) for each of the following: 16:1, 17:0, 18:0, and 20:0. These standards open the possibilities to identify AEL subtypes in tumours and compare their composition to those of non-tumour tissues.

PROCESS FOR PREPARING A POLYOL ETHER

The present invention relates to a process for preparing a polyol ether of formula (I), comprising a step of reductive alkylation involving a compound of general formula (II) and a compound of general formula (III): in which R1, R2, R3 and R4 are as defined in claim 1.

Synthesis of lipid-oligonucleotide conjugates for RNA interference studies

The synthesis of RNA molecules carrying lipids at their 3′-termini and 5′-termini is reported. These conjugates were fully characterized by MALDI-TOF mass spectrometry and HPLC chromatography. The ability of these conjugates to silence gene expression was